Proteasome Inhibitor IA selective inhibitor of chymotrypsin-like activities in the 26S proteasome (MCP)

Proteasome Inhibitor I (CAS 158442-41-2)

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Synonym: Z-Ile-Glu(OtBu)-Ala-Leu-CHO
Application: A selective inhibitor of chymotrypsin-like activities in the 26S proteasome (MCP)
CAS Number: 158442-41-2
Molecular Weight: 618.8
Molecular Formula: C32H50N4O8
* Refer to Certificate of Analysis for lot specific data (including water content).
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Proteasome Inhibitor is a synthetic peptide (Z-Ile-Glu(OtBu)-Ala-Leu-CHO) which selectively inhibits chymotrypsin-like activities in the 26S proteasome (MCP; multicatalytic proteinase complex) in HT4 cells. Additionally, Proteasome Inhibitor acts as anti-neoplytic agent and induces apoptosis in different leukemia cell lines. Furthermore Proteasome Inhibitor is an inhibitor for the deubiquitinating Enzyme, and causes accumulation of ubiquitinylated proteins in neuronal cells. Proteasome Inhibitor prevents the activation of NF-κB in response to TNF-α or okadaic acid through inhibition of IκBα degradation.


References

1. Traenckner, E.B. et al. 1994. EMBO J. 13(22): 5433-5441. PMID: 7957109
2. Figueiredo-Pereira, M.E. et al. 1994. J. Neurochem. 63(4): 1578-1581. PMID: 7931314
3. Mori, S. et al. 1995. J. Biol. Chem. 270(49): 29447-29452. PMID: 7493983
4. Griscavage, J.M. et al. 1996. Proc. Natl. Acad. Sci. U.S.A. 93(8): 3308-3312. PMID: 8622934

Usage :
Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C.
Appearance :
Lyophilized
Physical State :
Solid
Sequence :
Z-Ile-Glu(OtBu)-Ala-Leu-CHO
Storage :
Desiccate at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
71464413
SMILES :
CC[C@@H](C)[C@@H](C(=O)N[C@@H](CCC(=O)OC(C)(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C=O)NC(=O)OCC1=CC=CC=C1

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Certificate of Analysis

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Proteasome Inhibitor I  Product Citations

See how others have used Proteasome Inhibitor I. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 22020336  Fransson, S. et al. 2012. Oncogene. 31: 3277-86.

Citations 1 to 1 of 1 total
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