Procaine hydrochloride

Procaine hydrochloride (CAS 51-05-8)

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Application: A sodium channel blocker and DNA methylation inhibitor
CAS Number: 51-05-8
Molecular Weight: 272.77
Molecular Formula: C13H20N2O2 HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Procaine hydrochloride is a salt of the compound Procaine. Procaine is a noted sodium channel blocker with a variety of inhibitory effects. In skeletal muscle, Procaine has been reported to inhibit calcium-induced calcium release (CICR). Procaine is also noted to act as a DNA methylation inhibitor and to cause demethylation and reactivation of methylation-silenced genes such as RARβ and GSTP1. WIF-1 is noted to be reactivated in a cancer cell line and to downregulate the Wnt canonical pathway. In studies utilizing a neuroblastoma cell line (SHEP), Procaine is reported to induce neuronal apoptosis in a manner correlated with lipid solubility of the compound. In an adult mouse muscle cell line (HEK293), the presence of procaine is reported to potently inhibit nicotinic acetylcholine receptors. Procaine is available alone (sc-296134) and in its salt form as Procaine HCl (sc-250776).


References

1. Werdehausen, R., et al. 2009. Br J Anaesth. 103: 711-718. PMID: 19700777
2. Gao, Z.., et al. 2009. Oncol. Rep. 22: 1479-1484. PMID: 19885602
3. Endo, M. 2009. Physiol. Rev. 89: 1153-1176. PMID: 19789379
4. Wang, H., et al. 2010. Eur. J. Pharmacol. 630: 29-33. PMID: 20045405
5. Gal, R. and Libersat, F. 2010. PLoS ONE. 5: e10019. PMID: 20383324

Storage :
Store at 4° C
Melting Point :
153-158°C (lit)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
5795
MDL Number :
MFCD00013000
EC Number :
200-077-2
SMILES :
CCN(CC)CCOC(=O)C1=CC=C(C=C1)N.Cl

Download SDS (MSDS)

Certificate of Analysis

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