Proadifen hydrochloride An inhibitor of NOS1, AChR, cytochrome P-450, and KIR6.1

Proadifen hydrochloride (CAS 62-68-0)

Proadifen hydrochloride | CAS 62-68-0 is rated 5.0 out of 5 by 1.
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Synonym: 2-(diethylamino)ethyl 2,2-diphenylpentanoate hydrochloride; Propyladiphenin; SKF-525A HCl
Application: An inhibitor of NOS1, AChR, cytochrome P-450, and KIR6.1
CAS Number: 62-68-0
Molecular Weight: 389.96
Molecular Formula: C23H31NO2•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Proadifen hydrochloride sc-200492 250 mg $59.00
Proadifen hydrochloride sc-200492A 1 g $235.00

SKF-525A HCl (Proadifen) has many biochemical functions, some of which include: inhibitory effects on NOS1 (neuronal nitric oxide synthase; IC50 = 90 mM), adult mouse skeletal muscle AChR (acetyl choline receptor), hepatic drug metabolism via the CYP (cytochrome P450) system, CYP-dependent (cytochrome P450-dependent) arachidonate metabolism (90% at 50 μM), transmembrane calcium influx, and platelet thromboxane synthesis. This compound has also been shown to block KIR6.1 (ATP-sensitive inward rectifier potassium channel 8; IC50 = 4.4 mM) and stimulate endothelial cell prostacyclin production.


References

1. Lee, C.H., et al. 1976. J. Pharmacol. Exp. Ther. 198: 347-356. PMID: 7664
2. Galeotti, T., et al. 1983. Biochem. Pharmacol. 32: 3285-3295. PMID: 6651857
3. Carroll, M.A., et al. 1986. J Hypertens Suppl. 4: S33-S42. PMID: 3021941
4. Choo, L.K., et al. 1986. J. Pharm. Pharmacol. 38: 898-901. PMID: 2880963
5. Boeynaems, J.M., et al. 1986. Prostaglandins. 32: 145-149. PMID: 3532206
6. Kauser, K., et al. 1991. Circ. Res. 68: 1154-1163. PMID: 1901255
7. Khan, S., et al. 1993. Biochem. Pharmacol. 45: 439-447. PMID: 8435094
8. Holte, H.R., et al. 1996. Br. J. Pharmacol. 117: 1516-1520. PMID: 8730748
9. Spitzmaul, G., et al. 2009. Br. J. Pharmacol. 157: 804-817. PMID: 19422391

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (25 mg/ml), ethanol, and methanol.
Storage :
Store at room temperature
Melting Point :
122-123° C
IC50 :
glibenclamide-sensitive K+ channels: IC50 = 4.4 mM; neuronal nitric oxide synthase: IC50 = 90 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
YV7175000
PubChem CID :
65341
MDL Number :
MFCD00055151
SMILES :
CCCC(C1=CC=CC=C1)(C2=CC=CC=C2)C(=O)OCCN(CC)CC.Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Spitzmaul et al Spitzmaul et al. (PubMed ID 19422391) found that proadifen reduced the frequency and ampliatude of ACh-induced single-channel currents of adult mouse muscle AChR. -SCBT Publication Review
Date published: 2015-01-28
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