PPACK dihydrochloride An irreversible, potent inhibitor of thrombin and its downstream effects

PPACK dihydrochloride (CAS 142036-63-3)

PPACK dihydrochloride | CAS 71142-71-7 is rated 5.0 out of 5 by 1.
  • y_2019, m_4, d_20, h_3
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_201291, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 223ms
  • REVIEWS, PRODUCT
Synonym: D-Phe-Pro-Arg-CMK; D-Phenylalanyl-prolyl-arginyl Chloromethyl Ketone; D-Phe-Pro-Arg-chloromethylketone
Application: An irreversible, potent inhibitor of thrombin and its downstream effects
CAS Number: 142036-63-3
Molecular Weight: 523.88
Molecular Formula: C21H31ClN6O32HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

PPACK is known to be an irreversible and potent inhibitor of thrombin, as well as prothrombin, shown to inhibit thrombin activation of progelatinase A. Additionally, pretreatment with PPACK has been shown to inhibit thrombin-induced cerebral thromboembolism.


References

1. Liu, J.T., et al. 1994. Eur. J. Pharmacol. 264: 183-190. PMID: 7851481
2. Rahr, H.B., et al. 1994. Thromb. Res. 73: 279-284. PMID: 8016814
3. Zucker, S., et al. 1995. J. Biol. Chem. 270: 23730-23738. PMID: 7559545
4. Kereiakes, D.J., et al. 2001. J. Thromb. Thrombolysis. 12: 123-127. PMID: 11729363

Physical State :
Solid
Solubility :
Soluble in water (0.3 mg/ml) at 25° C.
Storage :
Store at -20° C
Density :
1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.64
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
13042154
SMILES :
C1C[C@H](N(C1)C(=O)[C@@H](CC2=CC=CC=C2)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)CCl.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

PPACK dihydrochloride  Product Citations

See how others have used PPACK dihydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 9 of 9 total

PMID: # 25418346  Jiménez-Alcázar, M. et al. 2015. J. Thromb. Haemost. 13: 732-42.

PMID: # 25094046  Wong, GW. et al. 2014. Biochem. Biophys. Res. Commun. 451: 314-8.

PMID: # 25264625  De Angelis, V. et al. 2014. PLoS ONE. 9: e108282.

PMID: # 22983162  Duong-Thi, MD. et al. 2013. Journal of biomolecular screening. 18: 160-71.

PMID: # 23479356  Duong-Thi, MD. et al. 2013. J Biomol Screen. 18: 748-55.

PMID: # 20525685  Suzuki-Inoue, K. et al. 2010. J. Biol. Chem. 285: 24494-24507.

PMID: # 16287616  Voss, R. et al. 2005. Platelets. 16: 492-497.

PMID: # 15105289  Chen, J. et al. 2004. Blood. 104: 1703-1710.

PMID: # 8393449  McHowat, J. et al. 1993. J. Biol. Chem. 268: 15605-15610.

Citations 1 to 9 of 9 total

What is the shipping temperature for this product?

Asked by: hawkeye11
This chemical, PPACK dihydrochloride (CAS 71142-71-7), ships on blue ice.
Answered by: Chemical Support 1
Date published: 2017-03-22
  • y_2019, m_4, d_21, h_11CST
  • bvseo_bulk, prod_bvqa, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_201291, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 83ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Worked well for our lab Worked well for our lab.
Date published: 2015-06-10
  • y_2019, m_4, d_21, h_11
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_201291, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 68ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.