Potassium Phosphate, Monobasic A useful reagent in formulating buffered solutions

Potassium Phosphate, Monobasic (CAS 7778-77-0)

Potassium Phosphate, Monobasic | CAS 7778-77-0 is rated 5.0 out of 5 by 1.
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Synonym: Potassium acid phosphate
Application: A useful reagent in formulating buffered solutions
CAS Number: 7778-77-0
Purity: ≥99%
Molecular Weight: 136.09
Molecular Formula: KH2PO4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Potassium Phosphate, Monobasic is a reagent with a very high buffering capacity and is widely used in molecular biology, biochemistry, and chromatography. Potassium phosphate occurs in several forms: monobasic (KH2PO4), dibasic (KH2PO4), and tribasic (K3PO4). Neutral potassium phosphate buffer solutions may be prepared with a mixture of the monobasic and dibasic forms to varying degrees, depending on the desired pH. Potassium Phosphate buffers are very useful in numerous applications, but with the following limitations: precipitation of Ca2+ and Mg2+, inhibition of restriction enzyme activity, and interference in DNA ligation or bacterial transformation protocols. Has been used to study the effects of freezing and thawing on the stability of proteins sensitive to conformational changes; it was found that KP buffers offered improved pH stability as opposed to NaP buffers. Potassium Phosphate has also been used for the extraction of keratohyalin protein from bovine tissue. It is an excellent source of phosphorus and potassium, has been used as a fungicide, and in its crystalline state it is noted for its non-linear optical properties.
Additional forms available:
Potassium Phosphate, Dibasic, Anhydrous (sc-203210)
Potassium phosphate tribasic (sc-250766)
Potassium phosphate tribasic monohydrate (sc-250767)
Potassium phosphate dibasic solution (sc-301600)
Potassium Phosphate Monobasic solution (sc-301601)


References

1. Da Costa, E.W. 1972. Appl Microbiol. 23: 46-53. PMID: 5062093
2. Schiel, J.E. and Hage, D.S. 2005. Talanta. 65: 495-500. PMID: 18969825
3. Dooleweerdt, K., et al. 2008. J. Org. Chem. 73: 9447-9450. PMID: 18991381
4. de Souza, R.L., et al. 2010. Appl. Biochem. Biotechnol. 161: 288-300. PMID: 20119857
5. Ugel, A.R. and Idler, W. 1972. J. Cell Biol. 52: 453-464. PMID: 5057980
6. Pikal-Cleland, K.A., et al. 2000. Arch. Biochem. Biophys. 384: 398-406. PMID: 11368330

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (100 mg/ml). Insoluble in ethanol.
Storage :
Store at room temperature
Melting Point :
252.6° C (lit.)
Density :
2.34 g/cm3 at 25° C
pK Values :
pKa: pK1: 2.15 (25° C), pK2: 6.82 (25° C), pK3: 12.38 (25° C)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
TC6615500
PubChem CID :
516951
Merck Index :
14: 7659
MDL Number :
MFCD00011401
EC Number :
231-913-4
SMILES :
OP(=O)(O)[O-].[K+]

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Certificate of Analysis

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Potassium Phosphate, Monobasic  Product Citations

See how others have used Potassium Phosphate, Monobasic. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 12679189  Lee, HS. et al. 2003. Life Sci. 72: 2719-2730.

PMID: # 11368330  Pikal-Cleland, KA. et al. 2000. Archives of biochemistry and biophysics. 384: 398-406.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Pikal Pikal-Cleland et al. (PubMed ID 11368330) found that proteins buffered with a potassium phosphate solution were more resistant to pH changes resulting from freezing than those buffered with a sodium phosphate alternative. -SCBT Publication Review
Date published: 2015-04-11
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