Polygodial Polygodial is a sesquiterpene that displays antinociceptive and antifungal properties. Found to down-regulate TRPV1 in spinal chord.

Polygodial  (CAS 6754-20-7)

Polygodial is rated 5.0 out of 5 by 1.
  • 2016-09-26T11:21CST
  • bvseo_cps, prod_bvrr, vn_cps_3.4.0
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_201489, PRD, sort_relevancy
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 94ms
  • REVIEWS, PRODUCT
| See 1 Citations
Synonym: (1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde
Application: A naturally occurring antifungal and antinociceptive
CAS Number: 6754-20-7
Purity: 97%
Molecular Weight: 234.33
Molecular Formula: C15H22O2
* Refer to Certificate of Analysis for lot specific data (including water content).
submit a review for this product and receive 15 cruzcredits

Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Polygodial sc-201489 5 mg $87.00
Polygodial sc-201489A 25 mg $334.00

Polygodial is a sesquiterpene isolated from the bark of Drymis winteri (winteraceae) plant that displays antinociceptive properties. In rat brain, polygodial has been shown to inhibit glutamate uptake in cortical, striatal, and hippocampal slices, as well as astrocytes, and increased synaptosomal glutamate release. These effects seem to activate an increase in the extracellular glutamate concentrations, possibly causing neurotoxic effects. In neonatal rat studies, polygodial was found to produce antinociception associated with TRPV1 down-regulation in the spinal cord. Polygodial has also been noted to have antifungal effects on dermatophytes such as E. floccosum. Furthermore, it has been reported that the antifungal properties of polygodial could be due to the uncoupling it causes in mitochondrial ATP synthesis by affecting the electrical properties of the membrane surface and eventually collapsing the membrane potential. Polygodial is an inhibitor of ATP5 and an activator of ANKTM1.


References

1. Andre, E., et al. 2004. Neuropharmacology. 46: 590-597. PMID: 14975683
2. Castelli, M.V., et al. 2005. Biochem. Pharmacol. 70: 82-89. PMID: 15894293
3. Malheiros, A., et al. 2008. J. Pharm. Pharm. Sci. 8: 335-339. PMID: 16124945
4. Martini, L.H. 2006. Neurochem. Res. 31: 431-438. PMID: 16733820

Physical State :
Solid
Solubility :
Soluble in DMSO (25 mg/ml), and ethanol (25 mg/ml).
Storage :
Store at -20° C
Melting Point :
98.21° C (Predicted)
Boiling Point :
330.73° C at 760 mmHg (Predicted)
Density :
1.09 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
IC50 :
TRPA1 channel: EC5050 = 400 nM; Photobacterium leiognathi : IC50 = 11400 nM; HT-29: IC50 = 2.5 ug.mL-1 (human); A549: IC50 = 2.5 ug.mL-1 (human); P388 : IC50 = 1.2 ug.mL-1 (mouse)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
QJ2850000
PubChem CID :
72503
MDL Number :
MFCD00238664
SMILES :
C[C@]12CCCC([C@@H]1CC=C([C@@H]2C=O)C=O)(C)C

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

You May Also Like

Polygodial Product Citations

See how others have used Polygodial. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 20890900
Mayan, MD. et al. 2010. Drug-induced permeabilization of S. cerevisiae. Curr Protoc Mol Biol. Chapter 13: -.

Citations 1 to 1 of 1 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 55ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Martini et al Martini et al. (PubMed ID 16733820) found that polygodial inhibited glutamate uptake by astrocytes and increased synaptosomal glutamate release. -SCBT Publication Review
Date published: 2015-03-05
  • 2016-09-26T11:21CST
  • bvseo_cps, prod_bvrr, vn_cps_3.4.0
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_201489, PRD, sort_relevancy
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 6ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2016 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.