PNU 22394 hydrochlorideA potent SR-2C agonist and partial SR-2A/SR-2B agonist

PNU 22394 hydrochloride (CAS 15923-78-1)

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Application: A potent SR-2C agonist and partial SR-2A/SR-2B agonist
CAS Number: 15923-78-1
Molecular Weight: 236.74
Molecular Formula: C13H16N2.HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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PNU 22394 hydrochloride is a potent SR-2C agonist and partial SR-2A/SR-2B agonist. It is non-selective between SR-2 subtypes. PNU 22394 hydrochloride reduces food intake in rats following subcutaneous administration and displays anorexigenic effects in humans.


References

McCall et al (2001) PNU-22394, a 5-HT2C receptor agonist, reduces feeding in rodents and produces weight loss in humans. Soc.Neurosci.Abstr. 27 309.2.

Physical State :
Solid
Solubility :
Soluble in water (100 mM).
Storage :
Desiccate at 4° C
Boiling Point :
409.7° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
Ki Data :
Recombinant SR-2C: Ki= 18 nM (human); Recombinant SR-2A: Ki= 18 nM (human); Recombinant SR-2B: Ki= 66 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16759162
MDL Number :
MFCD01665206
SMILES :
CN1C2=C(CCNCC2)C3=CC=CC=C31.Cl

Download SDS (MSDS)

Certificate of Analysis

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