PNU 22394 hydrochloride is a potent SR-2C agonist and partial SR-2A/SR-2B agonist. It is non-selective between SR-2 subtypes. PNU 22394 hydrochloride reduces food intake in rats following subcutaneous administration and displays anorexigenic effects in humans.
McCall et al (2001) PNU-22394, a 5-HT2C receptor agonist, reduces feeding in rodents and produces weight loss in humans. Soc.Neurosci.Abstr. 27 309.2.
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