PNU 142633 PNU 142633 is a very selective, high affinity SR-1D agonist.

PNU 142633  (CAS 187665-65-2)

PNU 142633 is rated 5.0 out of 5 by 1.
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Application: A high affinity SR-1D agonist
CAS Number: 187665-65-2
Molecular Weight: 422.53
Molecular Formula: C24H30N4O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
PNU 142633 sc-204204 10 mg $205.00

PNU 142633 is a very selective, high affinity SR-1D agonist (Ki values are 6 and > 18000 nM at human SR-1D and SR-1B, respectively). PNU 142633 blocks neurogenic plasma protein extravasation and inhibits sympathetically-induced tachycardic responses in vivo.


References

Roon et al (1999) Bovine isolated middle cerebral artery contractions to antimigraine drugs. Naunyn-Schmied.Arch.Pharmacol. 360 591. McCall et al (2002) Preclinical studies characterizing the anti-migraine and cardiovascular effects of the selective 5-HT1D receptor agonist PNU-142633. Cephalalgia 22 799. Sanchez-Lopez et al (2003) Pharmacological profile of the 5-HT-induced inhibition of cardioaccelerator sympathetic outflow in pithed rats: correlation with 5-HT1 and putative 5-ht5A/5B receptors. Br.J.Pharmacol. 140 725.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (20 mM).
Storage :
Store at 4° C
Melting Point :
287.06° C (Predicted)
Boiling Point :
652.51° C at 760 mmHg (Predicted)
Density :
1.20 g/cm3 (Predicted)
Refractive Index :
n20D 1.60 (Predicted)
Ki Data :
SR-1D: Ki= 4.6 nM (human)
pK Values :
pKb: 7.27 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9845148
MDL Number :
MFCD10687093
SMILES :
CNC(=O)C1=CC2=C(C=C1)[C@@H](OCC2)CCN3CCN(CC3)C4=CC=C(C=C4)C(=O)N

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from McCall et al McCall et al. (PubMed ID 12485205) found that PNU 142633, a highly selective 5-HT1D receptor agonist, blocked plasma protein extravasation and reduced the increase in cat nucleus trigeminal caudalis blood flow caused by electrical stimulation of the trigeminal ganglion. -SCBT Publication Review
Date published: 2015-07-02
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