PNU 142633 is a very selective, high affinity SR-1D agonist (Ki values are 6 and > 18000 nM at human SR-1D and SR-1B, respectively). PNU 142633 blocks neurogenic plasma protein extravasation and inhibits sympathetically-induced tachycardic responses in vivo.
Roon et al (1999) Bovine isolated middle cerebral artery contractions to antimigraine drugs. Naunyn-Schmied.Arch.Pharmacol. 360 591. McCall et al (2002) Preclinical studies characterizing the anti-migraine and cardiovascular effects of the selective 5-HT1D receptor agonist PNU-142633. Cephalalgia 22 799. Sanchez-Lopez et al (2003) Pharmacological profile of the 5-HT-induced inhibition of cardioaccelerator sympathetic outflow in pithed rats: correlation with 5-HT1 and putative 5-ht5A/5B receptors. Br.J.Pharmacol. 140 725.
Soluble in DMSO (100 mM), and ethanol (20 mM).
Store at 4° C
287.06° C (Predicted)
652.51° C at 760 mmHg (Predicted)
1.20 g/cm3 (Predicted)
n20D 1.60 (Predicted)
SR-1D: Ki= 4.6 nM (human)
pKb: 7.27 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Adobe Acrobat Reader is required to reliably view, print and comment on PDF documents
bvseo_sdk, java_sdk, bvseo-3.2.0
CLOUD, getContent, 168ms
bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of
McCall et alMcCall et al. (PubMed ID 12485205) found that PNU 142633, a highly selective 5-HT1D receptor agonist, blocked plasma protein extravasation and reduced the increase in cat nucleus trigeminal caudalis blood flow caused by electrical stimulation of the trigeminal ganglion. -SCBT Publication Review
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.