PMA A reversible and highly potent protein kinase C (PKC) activator

PMA (CAS 16561-29-8)

PMA | CAS 16561-29-8 is rated 4.8 out of 5 by 6.
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| See product citations (37)
Synonym: Phorbol-12-Myristate-13-Acetate; 12-O-Tetradecanoylphorbol 13-acetate, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate
Application: A reversible and highly potent protein kinase C (PKC) activator
CAS Number: 16561-29-8
Purity: ≥95%
Molecular Weight: 616.83
Molecular Formula: C36H56O8
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PMA sc-3576 1 mg $33.00
PMA sc-3576A 5 mg $109.00
PMA sc-3576B 10 mg $200.00

PMA (Phorbol-12-Myristate-13-Acetate) is a diester of phorbol and is a tumor promoting compound extracted from croton oil. It is a reversible, highly potent protein kinase C (PKC) activator in vitro and in vivo at nM concentrations. PMA's effects on PKC are attributed to its similarity to diacylgylerol, a natural activator of PKC. PMA activates Ca2+-ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.


1. Castagna, M., et al. 1982. J. Biol. Chem. 257: 7847-7851. PMID: 7085651
2. Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. U.S.A. 82: 2774-2778. PMID: 2859591
3. Saltis, J., et al. 1991. J. Biol. Chem. 266: 261-267. PMID: 1985898
4. Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73: 2011-2015. PMID: 1474079
5. Oishi, K. and Yamaguchi, M. 1994. J. Cell. Biochem. 55: 168-172. PMID: 8089192
6. Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. U.S.A. 92: 8443-8447. PMID: 7545303
7. Powell, D.J., et al. 2003. Mol. Cell. Biol. 23: 7794-7808. PMID: 14560023
8. Saraiva, L., et al. 2004. Eur. J. Pharmacol. 491: 101-110. PMID: 15140626
9. Shimura, C., et al. 2010. Am. J. Pathol. 176: 227-237. PMID: 20008150

Usage :
Dissolve in an DMSO or ethanol prior to dilution into aqueous buffers. Add calculated volume of organic solvent to vial to prepare concentrated stock solution. Intermediate dilutions into the same organic solvent are recommended prior to final dilution into aqueous buffer. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Appearance :
Amorphous film
Physical State :
Solubility :
Soluble in DMSO (25 mg/ml), 100%ethanol (25 mg/ml), acetone, ether, DMF, methanol, and chloroform. Insoluble in water, and aqueous buffers.
Storage :
Store at -20° C
Melting Point :
50-70° C
Boiling Point :
~698.10° C at 760 mmHg (Predicted)
Density :
1.17 g/cm3 (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
Optical Activity :
α24/D +49°, c = 1 in dioxane
Ki Data :
PKC: Ki= 2.6 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
Merck Index :
14: 7332
MDL Number :
Beilstein Registry :

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Certificate of Analysis

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PMAProduct Citations

See how others have used PMA. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 37 total

PMID: # 28554988
Mahdavi-Roshan, M. et al. 2017. Effects of garlic on brachial endothelial function and capacity of plasma to mediate cholesterol efflux in patients with coronary artery disease. Anatol J Cardiol. 18: 116-121.

PMID: # 28944482
Matsuoka, H. et al. 2017. Molecular mechanism for muscarinic M1 receptor-mediated endocytosis of TWIK-related acid-sensitive K+ 1 channels in rat adrenal medullary cells. J. Physiol. (Lond.). 595: 6851-6867.

PMID: # 29074567
Gendarme, M. et al. 2017. Image-based drug screen identifies HDAC inhibitors as novel Golgi disruptors synergizing with JQ1. Mol. Biol. Cell.

PMID: # 28092804
Gong, C. et al. 2017. Enhancement of NK cell-mediated lysis of non-small lung cancer cells by nPKC activator, ingenol 3,20 dibenzoate. Mol. Immunol.. 83: 23-32.

PMID: # 26854061
Du, J. et al. 2016. Extracellular matrix stiffness dictates Wnt expression through integrin pathway. Scientific reports. 6: 20395.

PMID: # 27731641
Tsai, JY. et al. 2016. Isolation of Phorbol Esters from Euphorbia grandicornis and Evaluation of Protein Kinase C- and Human Platelet-Activating Effects of Euphorbiaceae Diterpenes. J. Nat. Prod.. 79: 2658-2666.

PMID: # 27069117
Schmidt, FI. et al. 2016. A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly. The Journal of experimental medicine. 213: 771-90.

PMID: # 27043298
Lu, A. et al. 2016. Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism. Nature structural & molecular biology. 23: 416-25.

PMID: # 26204845
Kao, CT. et al. 2015. Tensile force on human macrophage cells promotes osteoclastogenesis through receptor activator of nuclear factor κB ligand induction. J. Bone Miner. Metab..

PMID: # 25435424
Dedinszki, D. et al. 2015. Inhibition of protein phosphatase-1 and -2A decreases the chemosensitivity of leukemic cells to chemotherapeutic drugs. Cell. Signal.. 27: 363-72.

Citations 1 to 10 of 37 total
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Rated 5 out of 5 by from work well Using PMA from Santa to active neutrophils to NETosis and it works well as the same product from Sigma
Date published: 2018-01-15
Rated 5 out of 5 by from Great PKC activator Ised this PKC activator many times with great results.
Date published: 2017-07-05
Rated 5 out of 5 by from well done We had used PMA for a long time(final conentration 10nmol-100nmol), PMA-treated THP-1 cells grew well and stable, and Western blot worked well too!
Date published: 2016-11-01
Rated 4 out of 5 by from thp-1 differentiate into macrophages thp-1 cells can differentiate into macrophages by using PMA.
Date published: 2016-11-01
Rated 5 out of 5 by from An increase in c An increase in c-Fos protein expression was observed (nuclear extracts) by WB in Jurkat cells post treatment with PMA. Other proteins affected by treatment with PMA include: p-PKC , caspase-6, p63 . -SCBT QC
Date published: 2015-02-01
Rated 5 out of 5 by from Zhou et Zhou et. al. (PubMed ID 23174781) used PMA to mimic Resistin to activate NF- B (via PKC - PKG signal transduction pathway). -SCBT QC
Date published: 2015-02-01
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