(+/-)-Bay K 8644 An active Ca2+ slow channel agonist

(±)-Bay K 8644 (CAS 71145-03-4)

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Synonym: 1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-[trifluoromethyl]phenyl)pyridine-3-carboxylic acid methyl ester
Application: An active Ca2+ slow channel agonist
CAS Number: 71145-03-4
Purity: >98%
Molecular Weight: 356.30
Molecular Formula: C16H15F3N2O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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(±)-Bay K 8644 is a L-type Ca2+-channel activator (EC50 = 17.3 nM) with positive inotropic, vasoconstrictive and behavioral effects in vivo. When used with BIX-01294 (sc-293525), (±)-Bay K 8644 helps generate induced pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs). (±)-Bay K 8644 also inhibits autophagy.


1. Wang, W., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 1427. 2. Weigl, L.G., et al. 2000. J. Physiol. 525 (pt. 2), 461. 3. Vannier, C., et al. 1995. Am. J. Physiol. 268, L201. 4. Bechem, M., and Hoffmann, H. 1993. Pflugers Arch. 424, 343. 5. Triggle, D.J., and Rompe, D. 1989. Trends Pharmacol. Sci. 10, 507. 6. Takasu, N., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1107. 7. Tagliatela, M., et al. 1986. Brain Res. 381, 356. 8. Franckowiak, G., et al. 1985. Eur. J. Pharmacol. 114, 223.

Physical State :
Solubility :
Soluble in DMSO (20 mg/ml), methanol (63 mg/ml), ethanol (63 mg/ml), dichloromethane, and DMF. Insoluble in water.
Storage :
Store at 4° C
Melting Point :
168-170° C
Boiling Point :
~429.17° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.54 (Predicted)
IC50 :
L-type Ca2+-channel : EC5050 = 17.3 nM; Cavia porcellus: IC50 = 230 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
MDL Number :

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Certificate of Analysis

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