Plumbagin exhibits cytotoxicity in rodent models of carcinogenesis and carcinoma and shows has antifungal, antiviral, and antibacterial action. Plumbagin also suppresses CXCR4 expression, a key component of cancer metastasis studies.
Hsu, Y.L., et al., , Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) induces apoptosis and cell cycle arrest in A549 cells through p53 accumulation via c-Jun NH2-terminal kinase-mediated phosphorylation at serine 15 in vitro and in vivo. J. Pharmacol. Exp. Ther. 318, 484-494, (2006) Sugie, S., et al., Inhibitory effects of plumbagin and juglone on azoxymethane-induced intestinal carcinogenesis in rats. Cancer Lett. 127, 177-183, (1998) Inbaraj, J.J., and Chignell, C.F., Cytotoxic action of juglone and plumbagin: a mechanistic study using HaCaT keratinocytes. Chem. Res. Toxicol. 17, 55-62, (2004) Jaiswal, A.S., et al., Long-patch base excision repair of apurinic/apyrimidinic site DNA is decreased in mouse embryonic fibroblast cell lines treated with plumbagin: involvement of cyclin-dependent kinase inhibitor p21Waf-1/Cip-1. Oncogene 21, 5912-5922, (2002)
See how others have used Plumbagin. Click on the entry to view the PubMed entry .
PMID: # 28249720 Zhang, J. et al. 2017. Arch. Biochem. Biophys. 619: 16-26.
PMID: # 22669514 Patridge, EV. et al. 2012. Arch. Toxicol. 86: 1613-25.
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