PKI (6-22) amide A synthetic peptide that acts as a protein kinase inhibitor

PKI (6-22) amide (CAS 121932-06-7)

PKI (6-22) amide | CAS 121932-06-7 is rated 5.0 out of 5 by 1.
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Synonym: PKA Inhibitor; Protein Kinase A Inhibitor Fragment 6-22 amide
Application: A synthetic peptide that acts as a protein kinase inhibitor
CAS Number: 121932-06-7
Purity: ≥97%
Molecular Weight: 1868.06
Molecular Formula: C80H130N28O24
* Refer to Certificate of Analysis for lot specific data (including water content).
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PKI (6-22) amide is a synthetic peptide that acts as a protein kinase inhibitor. The compound has been shown to inhibit PKA by binding to the substrate site of PKA (IC50 < 2 nM). MDA-MB231 breast cancer cell research indicates that the antiproliferative effects of PKI (6-22) amide are associated to the cAMP-PKA pathway, due to its ability to revert the effects of oxytocin.


References

1. Glass, D.B., et al. 1989. J. Biol. Chem. 264: 14579-14584. PMID: 2760075
2. Cassoni, P., et al. 1997. Int. J. Cancer. 72: 340-344. PMID: 9219843
3. Liu, H., et al. 2009. Mol. Pharmacol. 76: 1290-1301. PMID: 19734321
4. Ribeiro, R.A., et al. 2010. Br J Nutr. 1-8. PMID: 20591207

Physical State :
Solid
Sequence :
H-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2
Solubility :
Soluble in water, and 20% acetonitrile (1 mg/ml).
Storage :
Store at -20° C
Density :
~1.5 g/cm3 (Predicted)
IC50 :
PKA: IC50 = < 2 nM
Ki Data :
PKA: Ki= 2.5 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
MDL Number :
MFCD00133792
SMILES :
[H]/N=C(\N)/NCCC[C@@H](C(=O)N[C@@H](CCCN/C(=N/[H])/N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCN/C(=N/[H])/N)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H]([C@@H](C)O)N

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Certificate of Analysis

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PKI (6-22) amide  Product Citations

See how others have used PKI (6-22) amide. Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 25428621  Cui, M. et al. 2016. Mol. Neurobiol. 53: 240-53.

PMID: # 24825897  Kang, Q. et al. 2014. The Journal of biological chemistry. 289: 17480-96.

PMID: # 22977257  Kocieda, VP. et al. 2012. J. Biol. Chem. 287: 36922-35.

PMID: # 22637478  Ochoa, CD. et al. 2012. J. Biol. Chem. 287: 25407-18.

PMID: # 12642178  Araujo, AP. et al. 2003. Behav. Brain Res. 139: 75-81.

Citations 1 to 5 of 5 total
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Rated 5 out of 5 by from Araujo et al Araujo et al. (PubMed ID 12642178) studied cAMP-dependent effects of cocaine on PKA by using PKI (6-22) amide to inhibit PKA activity. -SCBT Publication Review
Date published: 2015-05-18
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