PKG Inhibitor PKG inhibitor is a specific cGKI (cyclic GMP-dependent protein kinase) inhibitor reported to block NMDA potentiation and GABA nitric oxide depression.

PKG Inhibitor  (CAS 82801-73-8)

PKG Inhibitor is rated 5.0 out of 5 by 1.
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Synonym: arginyl-lysyl-arginyl-alanyl-arginyl-lysyl-glutamic acid; [Ala32]-Histone H2B (29-35)
Application: A specific cyclic GMP-dependent protein kinase (cGKI) inhibitor
CAS Number: 82801-73-8
Molecular Weight: 943.11
Molecular Formula: C38H74N18O10
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
PKG Inhibitor sc-201161 1 mg $71.00

PKG inhibitor is a specific cGKI (cyclic GMP-dependent protein kinase) inhibitor. Data indicates that it does not block cyclic GMP-dependent protein kinase phosphorylation of intact histones and has been used to study Plasmodium falciparum. NMDA potentiation and GABA nitric oxide depression have been reported to be blocked by the PKG inhibitor. Other PKG inhibitors include KT5823 (sc-3534), which activates apoptotic DNA fragmentation.


References

1. Glass, D.B. 1983. Biochem. J. 213: 159-164. PMID: 6615418
2. Wexler, E.M., et al. 1998. J. Neurosci. 18: 2342-2349. PMID: 9502795
3. Wei, J.Y., et al. 2002. Brain Res. 927: 42-54. PMID: 11814431
4. Chan, S.L. and Fiscus, R.R. 2003. Mol. Hum. Reprod. 9: 775-783. PMID: 14614039
5. Diaz, C.A., et al. 2006. Mol. Biochem. Parasitol. 146: 78-88. PMID: 16325279

Formulation :
Counter ion: Acetate
Physical State :
Solid
Sequence :
Arg-Lys-Arg-Ala-Arg-Lys-Glu
Solubility :
Soluble in water.
Storage :
Store at -20° C
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.66
Ki Data :
PKG: Ki= 86 µM; PKA: Ki= 550 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
134097
MDL Number :
MFCD00080098
SMILES :
C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)N

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Wexler Wexler, EM. et al. (PubMed 9502795) used the PKG Inhibitor to demonstrate that nitric oxide depresses GABAA receptor function via coactivation of cGMP-dependent kinase and phosphodiesterase. -SCBT Publication Review
Date published: 2015-03-12
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