PKC theta Pseudo-substrate Inhibitor Inhibitor for in vitro PKCθ kinase assays

PKC θ Pseudo-substrate Inhibitor

PKC θ Pseudo-substrate Inhibitor is rated 5.0 out of 5 by 1.
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Synonym: Protein Kinase Cθ Pseudosubstrate Inhibitor; LHQRRGAIKQAKVHHVKC
Application: Inhibitor for in vitro PKCθ kinase assays
Purity: ≥97% by HPLC
Molecular Weight: 2109.5
Molecular Formula: C91H157N35O21S
* Refer to Certificate of Analysis for lot specific data (including water content).
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PKC θ Pseudo-substrate inhibitor is a protein kinase Cθ pseudosubstrate peptide that can be used as a competitive inhibitor for in vitro PKC θ kinase assays.


References

1. Osada, S., Mizuno, K., Saido, T.C., Suzuki, K., Kuroki, T. and Ohno, S. 1992. A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle. Mol. Cell. Biol. 12(9): 3930-3938. PMID: 1508194

Usage :
Recommended reaction conditions: PKCθ-containing sample is incubated at 30 - 37°C, with or without 400 μM PKC θ Pseudo-substrate inhibitor, in 50 mM Tris buffer (pH 7.5) containing 5 mM MgCl2, 0.1 mM Na3VO4, 0.1 mM Na4P2O7, 1 mM NaF, 0.1 mM PMSF, 50 μM ATP, 5 μCi [γ-32P]ATP, 4 μg phosphatidylserine, and 40 μM PKCθ substrate (sc-3107).

Storage:Protect from moisture. After reconstitution, aliquot and freeze (-20°C). This product is stable for 2 years as supplied. Stock solutions are stable for 6 months -20°C.
Appearance :
Lyophilized
Physical State :
Solid
Sequence :
Leu-His-Gln-Arg-Arg-Gly-Ala-Ile-Lys-Gln-Ala-Lys-Val-His-His-Val-Lys-Cys-OH
Solubility :
Soluble in water.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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Certificate of Analysis

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PKC theta Pseudo-substrate Inhibitor  Product Citations

See how others have used PKC theta Pseudo-substrate Inhibitor. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 25277212  Leung, CS. et al. 2014. Nature communications. 5: 5092.

PMID: # 19706599  Gayen, JR. et al. 2009. The Journal of biological chemistry. 284: 28498-509.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Various publications cite the use of PKC Pseudo Various publications cite the use of PKC Pseudo-substrate inhibitor, a protein kinase C pseudosubstrate peptide, as a competitive inhibitor for in vitro PKC kinase assays. -SCBT Publication Review
Date published: 2015-01-25
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