Pizotifen malate, a derivative of benzocycloheptathiophene, is a tricyclic compound found to be a potent inhibitor of SR-2 receptor activity. In addition, it has been found to display vasoconstrictor activity in vivo. Studies on mice suggest that Pizotifen malate may have embryotoxic effects due to decreased value of mitotic indices in bone marrow cells. Pizotifen malate has also been reported to have acute antagonistic affects on central muscarinic receptors.
1. Ujházy, E., et al. 1988. Agents Actions. 23: 376-378. PMID: 3394590 2. Peroutka, S.J. 1988. Ann. Neurol. 23: 500-504. PMID: 2898916 3. Mylecharane, E.J. 1991. J. Neurol. 238: S45-S52. PMID: 2045831 4. Collado, D., et al. 1993. Physiol. Behav. 53: 161-165. PMID: 8434056
Soluble in water (3 mg/ml), and DMSO (30 mg/ml).
Store at room temperature
5-HT3: Ki= 42 nM; 5-HT2: Ki= 1-10 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of
RahmanRahman, SM. et al. (PubMed 20884459) developed an isocratic reversed phase high-performance liquid chromatographic method for quantification of Pizotifen malate in pharmaceutical solid dosage formulations. The method showed high sensitivity with good linearity (r(2)= 0.99997) over the tested concentration range of 0.0020-0.0300 mg/ml for Pizotifen malate. Detection was carried out at 231 nm and retention time was 2.838 min. -SCBT Publication Review
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.Hide
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.