Pitavastatin Lactone is a major phase 2 metabolite of pitavastatin, an inhibitor of HMG-CoA reductase. Studies have shown that conversion between the acid and lactone forms of pitavastatin occurs in the body and that these two forms differ in substrate activity tow.
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For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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TobaToba, H. et al. (PubMed 20678154) found that Pitavastatin Lactone, an HMG-CoA reductase inhibitor, shows renoprotective effects against diabetic nephropathy mediated in part by inhibition of the renal rennin-angiotensin-aldosterone system, including the suppression of angiotensin-converting enzyme expression and aldosterone production. -SCBT Publication Review
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