Pitavastatin Lactone An HMG-CoA reductase inhibitor

Pitavastatin Lactone (CAS 141750-63-2)

Pitavastatin Lactone | CAS 141750-63-2 is rated 5.0 out of 5 by 1.
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Application: A major phase 2 metabolite of pitavastatin, an inhibitor of HMG-CoA reductase
CAS Number: 141750-63-2
Purity: ≥95%
Molecular Weight: 403.45
Molecular Formula: C25H22FNO3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Pitavastatin Lactone is a major phase 2 metabolite of pitavastatin, an inhibitor of HMG-CoA reductase. Studies have shown that conversion between the acid and lactone forms of pitavastatin occurs in the body and that these two forms differ in substrate activity tow.


References

1. Miners, J.O., et al. 2002. Toxicology 181: 453-456. PMID: 12505351
2. Prueksaritanont, T., et al. 2002. Drug Metab. Dispos. 30: 505-512. PMID: 11950779
3. Benet, L.Z., et al. 2003. Curr. Drug Metab. 4: 393-398. PMID: 14529371
4. Lin, J., et al. 2003. Clin. Pharmacokinet. 42: 59-98. PMID: 12489979
5. Fujino, H., et al. 2004. Xenobiotica. 34: 961-971. PMID: 15801541
6. Yamada, I., et al. 2003. Xenobiotica. 33: 789-803. PMID: 12893526
7. Tian, L., et al. 2008. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 865: 127-132. PMID: 18342583

Appearance :
Powder
Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9801294
SMILES :
OC1C[C@H](OC(=O)C1)\C=C\C1=C(C2=CC=C(F)C=C2)C2=CC=CC=C2N=C1C1CC1

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Pitavastatin Lactone  Product Citations

See how others have used Pitavastatin Lactone. Click on the entry to view the PubMed entry .

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PMID: # 25318994  Hosaka, S. et al. 2015. Drug Metab. Dispos. 43: 27-33.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Toba Toba, H. et al. (PubMed 20678154) found that Pitavastatin Lactone, an HMG-CoA reductase inhibitor, shows renoprotective effects against diabetic nephropathy mediated in part by inhibition of the renal rennin-angiotensin-aldosterone system, including the suppression of angiotensin-converting enzyme expression and aldosterone production. -SCBT Publication Review
Date published: 2015-05-03
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