PiperazineA buffer component in chromatography purifications and separations based on pH

Piperazine (CAS 110-85-0)

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Synonym: 1,4-Diazacyclohexane; Diethylenediamine
Application: A buffer component in chromatography purifications and separations based on pH
CAS Number: 110-85-0
Molecular Weight: 86.14
Molecular Formula: C4H10N2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Buffer component; the pH of a 10% aqueous solution is 10.8-11.8. Used as a buffer component in chromatography purifications and/or separations based on pH. The piperazine scaffold is frequently found in biologically active compounds across a number of different therapeutic areas. Some therapeutic areas include antifungals, antidepressants, antiviral, and serotonin receptor (5-HT) antagonists/agonists. Has been used since the 1950's as an anthelmintic, especially in horses and dogs. The anthelmintic properties of piperazine compounds is by paralysis of the parasites; this action is mediated by its agonistic effects on the GABA receptor. Wide variety of additional applications include use as an intermediate for pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.


References

1. Blechschmidt, B., et al. 1992. J. Gen. Microbiol. 138: 1197-1202. PMID: 1527494
2. Jones, R.G., et al. 2002. J. Immunol. Methods. 263: 57-74. PMID: 12009204

Usage :
Turns dark on exposure to light. Piperazine readily absorbs water and carbon dioxide from the air.
Physical State :
Solid
Storage :
Store at room temperature
Melting Point :
109-112° C (lit.)
Boiling Point :
145-146° C (lit.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
4837
SMILES :
C1CNCCN1

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Certificate of Analysis

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