Pifithrin-μ is a cell-permeable sulfonamide inhibitor of p53 binding and an anti-apoptotic. Direct inhibition of p53 binding to mitochondria as well as to Bcl-xL and Bcl-2 proteins by Pifithrin-μ has been observed. Pifithrin-μ selectively inhibits p53 translocation to mitochondria without affecting the transactivation function of p53. Pifithrin-μ has been shown to reduce γ-radiation induced cell death in vitro. Unlike pifithrin-α (sc-45050), pifithrin-μ targets only the mitochondrial branch of the p53 pathway without affecting the important transcriptional functions of p53. Pifithrin-μ selectively inhibits HSP 70 (heat shock protein 70) activity.
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See how others have used Pifithrin-mu. Click on the entry to view the PubMed entry .
PMID: # 26884717 Yu, W. et al. 2016. Int. J. Biol. Sci. 12: 198-209.
PMID: # 26703711 Claus, C. et al. 2015. Viruses. 7: 6108-26.
PMID: # 24244355 Sekihara, K. et al. 2013. PLoS ONE. 8: e78772.
PMID: # 19955567 Hagn, F. et al. 2010. J. Biol. Chem. 285: 3439-3450.
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