Pidotimod is a synthetic dipeptide with immunological modulatory activity on both the adaptive and innate immune responses. This compound has been shown to induce dendritic cell maturation and up-regulate the expression of HLA-DR and co-stimulatory molecules CD83 and CD86, which are integral to communication with adaptive immunity cells. Pidotimod has also been shown to stimulate dendritic cells to release pro-inflammatory molecules such as MCP-1 and TNF-α cytokines, and to inhibit thymocyte apoptosis caused by a variety of apoptosis inducing molecules.
1. Migliorati, G., et al. 1994. Arzneimittelforschung. 44: 1421-1424. PMID: 7857335 2. Gourgiotis, D., et al. 2004. J Asthma. 41: 285-287. PMID: 15260461 3. Riboldi, P., et al. 2009. Int J Immunopathol Pharmacol. 22: 255-262. PMID: 19505378 4. Giagulli, C., et al. 2009. Int. Immunopharmacol. 9: 1366-1373. PMID: 19712757
Soluble in water (37.8 g/L), methanol (13.8 g/L), ethanol (4.4 g/L), and DMF (72.4 g/L).
Store at 4° C
663° C at 760 mmHg
~1.5 g/cm3 (Predicted)
n20D 1.62 (Predicted)
α20/D -150°, c = 2 in 5NHCl
pKa: 2.95 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Giagulli et alGiagulli et al. (PubMed ID 19712757) found that pidotimod, a synthetic capable of modulating immune cell functions, induced mucosal dendritic cell maturation and promoted the activation of the innate immune system. -SCBT Publication Review
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