Pidotimod A synthetic dipeptide with immunological modulatory activity on both the adaptive and innate immune responses

Pidotimod (CAS 121808-62-6)

Pidotimod | CAS 121808-62-6 is rated 5.0 out of 5 by 1.
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Synonym: (4R)-3-{[(2S)-5-oxopyrrolidin-2-yl]carbonyl}-1,3-thiazolidine-4-carboxylic acid; (R)-3-((S)-5-Oxoprolyl)-4-thiazolidinecarboxylic acid
Application: A synthetic dipeptide with immunological modulatory activity on both the adaptive and innate immune responses
CAS Number: 121808-62-6
Purity: ≥98%
Molecular Weight: 244.27
Molecular Formula: C9H12N2O4S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Pidotimod is a synthetic dipeptide with immunological modulatory activity on both the adaptive and innate immune responses. This compound has been shown to induce dendritic cell maturation and up-regulate the expression of HLA-DR and co-stimulatory molecules CD83 and CD86, which are integral to communication with adaptive immunity cells. Pidotimod has also been shown to stimulate dendritic cells to release pro-inflammatory molecules such as MCP-1 and TNF-α cytokines, and to inhibit thymocyte apoptosis caused by a variety of apoptosis inducing molecules.


References

1. Migliorati, G., et al. 1994. Arzneimittelforschung. 44: 1421-1424. PMID: 7857335
2. Gourgiotis, D., et al. 2004. J Asthma. 41: 285-287. PMID: 15260461
3. Riboldi, P., et al. 2009. Int J Immunopathol Pharmacol. 22: 255-262. PMID: 19505378
4. Giagulli, C., et al. 2009. Int. Immunopharmacol. 9: 1366-1373. PMID: 19712757

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (37.8 g/L), methanol (13.8 g/L), ethanol (4.4 g/L), and DMF (72.4 g/L).
Storage :
Store at 4° C
Melting Point :
197-204° C
Boiling Point :
663° C at 760 mmHg
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
Optical Activity :
α20/D -150°, c = 2 in 5NHCl
pK Values :
pKa: 2.95 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
XJ5426675
PubChem CID :
65944
Merck Index :
12: 7574
MDL Number :
MFCD00867583
Beilstein Registry :
6636310
SMILES :
C1CC(=O)NC1C(=O)N2CSCC2C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Giagulli et al Giagulli et al. (PubMed ID 19712757) found that pidotimod, a synthetic capable of modulating immune cell functions, induced mucosal dendritic cell maturation and promoted the activation of the innate immune system. -SCBT Publication Review
Date published: 2015-01-09
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