Picotamide A dual inhibitor of thromboxane A2 and thromboxane A2 synthase

Picotamide (CAS 32828-81-2)

Picotamide | CAS 32828-81-2 is rated 5.0 out of 5 by 1.
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Application: A dual inhibitor of thromboxane A2 and thromboxane A2 synthase
CAS Number: 32828-81-2
Purity: ≥98%
Molecular Weight: 376.2
Molecular Formula: C21H20N4O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Picotamide is a dually active TXA2R (thromboxane A2) and TXA synthase (thromboxane A2 synthase) inhibitor. It has been shown to exhibit platelet inhibitory effects ex vivo and in vitro. It suppresses arachidonic acid, low-dose collagen, and TXA2-induced human platelet aggregation. However, it does not afftect A23187 induced aggregation or primary aggregation by ADP. It has been shown to inhibit the synthesis of TXA2 by platelets in a dose dependent fashion. It has been reported to enhance PGE2 formation, and enhance PGI2 formation by aspirinated endothelial cells. It has also been shown to raise intraplatelet cAMP levels in platelets stimulated with arachidonic acid.


References

1. Modesti, P.A., et al. 1989. Eur. J. Pharmacol. 169: 85-93. PMID: 2532145
2. Gresele, P., et al. 1989. Thromb. Haemost. 61: 479-484. PMID: 2552606
3. Berrettini, M., et al. 1990. Eur. J. Clin. Pharmacol. 39: 495-500. PMID: 1963845

Physical State :
Solid
Solubility :
Soluble in DMSO (25 mg/ml), and ethanol (25 mg/ml). Insoluble in water.
Storage :
Store at room temperature
Melting Point :
128-131° C
Boiling Point :
~688.1° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.62
pK Values :
pKa: 13.31, pKb: 4.75
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
CZ2235500
PubChem CID :
4814
Merck Index :
14: 7407
MDL Number :
MFCD00866792
EC Number :
251-245-7
SMILES :
COC1=C(C=C(C=C1)C(=O)NCC2=CN=CC=C2)C(=O)NCC3=CN=CC=C3

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Berrettini et al Berrettini et al. (PubMed ID 1963845) found that the prostanoid inhibitor, picotamide, prevented platelet aggregation and clot formation via thromboxane B2-synthase inhibition and thromboxane A2 antagonism. -SCBT Publication Review
Date published: 2015-02-03
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