Phytic acid dipotassium salt A potent chelator of divalent and trivalent cations

Phytic acid dipotassium salt (CAS 129832-03-7)

Phytic acid dipotassium salt | CAS 129832-03-7 is rated 5.0 out of 5 by 1.
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Synonym: Inositol hexakisphosphate; Inositol hexaphosphoric acid
Application: A potent chelator of divalent and trivalent cations
CAS Number: 129832-03-7
Purity: ≥95%
Molecular Weight: 736.22
Molecular Formula: C6H16O24P62K
* Refer to Certificate of Analysis for lot specific data (including water content).
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Phytic acid dipotassium salt is present in all eukaryotic cells. In plants, phytic acid dipotassium salt functions as a [PO4]3- storage depot and precursor for other inositol phosphates and pyrophosphates. Its high surface negative charge makes it a potent chelator of divalent and trivalent cations in vitro. In yeast, phytic acid acts with the nuclear pore protein Gle1 to regulate the nuclear export of mRNA by coactivating the RNA-dependent ATPase activity of DExD-box protein 5 (Dbp5).


References

Shears, S.B., Assessing the omnipotence of inositol hexakisphosphate. Cell. Signal. 13, 151-158, (2001) Raboy, V., myo-Inositol-1,2,3,4,5,6-hexakisphosphate. Phytochemistry 64, 1033-1043, (2003) Weirich, C.S., et al., Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA export. Nat. Cell Biol. 8, 668-676, (2006) Alcazar-Roman, A.R., et al., Inositol hexakisphosphate and Gle1 activate the DEAD-box protein Dbp5 for nuclear mRNA export. Nat. Cell Biol. 8, 711-716, (2006)

Appearance :
Powder
Physical State :
Solid
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
22838972
MDL Number :
MFCD00133773
SMILES :
C1(C(C(C(C(C1OP(=O)(O)O)OP(=O)(O)O)OP(=O)([O-])[O-])OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O.[K+].[K+]

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Rated 5 out of 5 by from Fu Fu, et al. (PubMed ID 26385515) reported that phytic acid (IP6) modulates the TJ proteins' localization and down regulates expression of TJ proteins (including claudin-1, occludin and ZO-1), leading to a loss in integrity of Caco-2 cell monolayers. -SCBT Publication Review
Date published: 2015-06-07
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