Physcion An anthraquinone originally isolated from Rheum emodi

Physcion (CAS 521-61-9)

Physcion | CAS 521-61-9 is rated 5.0 out of 5 by 1.
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Synonym: 1,8-Dihydroxy-3-methoxy-6-methylanthraquinone, Emodin-3-methyl ether
Application: An anthraquinone originally isolated from Rheum emodi
CAS Number: 521-61-9
Purity: ≥98%
Molecular Weight: 284.26
Molecular Formula: C16H12O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Physcion is an anthraquinone isolated from Rheum emodi. Has antitumor and antifungal activity.


References

1. Kuo, Y.C., et al. 1997. Life Sci. 61: 2335-2344. PMID: 9408056
2. Agarwal, S.K., et al. 2000. J. Ethanopharmacol. 72: 43-46. PMID: 10967452

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (immiscible), Hexane, methylene chloride, and chloroform.
Storage :
Store at room temperature
Melting Point :
202-204° C (dec.)
Boiling Point :
560.53° C at 760 mmHg (Predicted)
Density :
1.45 g/cm3 (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
Neutrophil Elastase: IC50 = 6.2 µM (human); HCT-116: IC50 = 19 µM (human); HepG2: IC50 = 77.3 µM (human); TrxR2: IC50 = 132 µM (rat); Human rhinovirus A protease: IC50 = >150 µM (human rhinovirus sp.)
Ki Data :
P2Y12: Ki= >10 µM (human)
pK Values :
pKa: 6.23 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
CB6720000
PubChem CID :
10639
MDL Number :
MFCD00017374
EC Number :
208-315-7
Beilstein Registry :
6770499
SMILES :
CC1=CC(=C2C(=C1)C(=O)C3=CC(=CC(=C3C2=O)O)OC)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Kuo et al Kuo et al. (PubMed ID 9408056) found that physcion inhibited tumor cell proliferation in K562 cells. -SCBT Publication Review
Date published: 2015-01-24
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