Phloxine B A phenyl-xanthene dye which is an inhibitor of UDP-glucuronosyltransferase and PARG; a photoactive dye with efficacy against gram-positive organisms.

Phloxine B  (CAS 18472-87-2)

Phloxine B is rated 5.0 out of 5 by 1.
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| See 1 Citations
Synonym: Acid Red 92; Cyanosine
Application: A fluorescein photoactive dye
CAS Number: 18472-87-2
Molecular Weight: 829.63
Molecular Formula: C20H2Br4Cl4O52Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Phloxine B sc-203753 25 g $107.00
Phloxine B sc-203753A 100 g $200.00

Phloxine B is a fluorescein dye which is known to inhibit the enzyme UDP-glucuronosyltransferase (UGT), the main catalyst for the glucuronidation of 7-HC. Additionally, Phloxine B is reported to be a poly(ADP-ribose) glycohydrolase (PARG) inhibitor. As a photoactive dye, Phloxine B is reported to have efficacy against gram-positive organisms. Phloxine B has also been utilized in a study investigating the visible light-induced photodegradation kinetics when coated onto silica TLC plates and in solution. The rapid photodegradation of Phloxine B via visible light exposure was noted and the phototoxicity of the remaining residues were also reported to be decreased.


References

1. Slabbert, J.C., et al. 1990. J Esthet Dent. 2: 177-180. PMID: 2088435
2. Wang, H., et al. 2008. Biomed. Environ. Sci. 21: 438-441. PMID: 19133619
3. Brovko, L.Y., et al. 2009. J. Food Prot. 72: 1020-1024. PMID: 19517729
4. van Midwoud, P.M., et al. 2010. Anal. Chem. [Epub ahead of print]. PMID: 21128611

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (1 mg/ml) (clear red solution).
Storage :
Store at room temperature
pK Values :
pKa: 1.32
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
LM5900000
PubChem CID :
6433718
Merck Index :
14: 10471
MDL Number :
MFCD00070627
EC Number :
242-355-6
Beilstein Registry :
3887100
SMILES :
C1=C2C(=C(C(=C1Br)[O-])Br)OC3=C(C(=C(C=C3C24C5=C(C(=C(C(=C5Cl)Cl)Cl)Cl)C(=O)O4)Br)[O-])Br.[Na+].[Na+]

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Certificate of Analysis

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Phloxine B Product Citations

See how others have used Phloxine B. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 22291963
Tanae, K. et al. 2012. Histone chaperone Asf1 plays an essential role in maintaining genomic stability in fission yeast. PLoS ONE. 7: -.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Van Midwoud et al Van Midwoud et al. (PubMed ID 21128611) showed that Phloxine B showed a concentration-dependent inhibition of 7-HC glucuronide formation and allowed the calculation of an IC50 value using one single liver slice. -SCBT Publication Review
Date published: 2015-05-25
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