Phleomycin A metal-complexing DNA degrading antibiotic

Phleomycin (CAS 11006-33-0)

Phleomycin | CAS 11006-33-0 is rated 5.0 out of 5 by 1.
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Synonym: Phleomycin complex; Phleomycins
Application: A metal-complexing DNA degrading antibiotic
CAS Number: 11006-33-0
Molecular Weight: 1326.37
Molecular Formula: C51H75N17O21S2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Phleomycin is an antibiotic closely related to Bleomycin (sc-200134). Phleomycin and Bleomycin are both described to form Cu(II)-complexes which approximate DNA and induce oxidative DNA degradation. Intercalation is not observed with the Cu(II)-Phleomycin complex, indicating that the intercalation demonstrated by Bleomycin complexes is not requisite for DNA degradation. The oxidative DNA degradation induced by Phleomycin-metal complexes is suggested to be mediated by intermediate oxidation of free thiols to their radical forms.


References

1. Sleigh, M.J. and Grigg, G.W. 1977. Mutat. Res. 42: 181-190. PMID: 320461
2. Povirk, L.F., et al. 1981. Biochemistry. 20: 665-671. PMID: 6163448

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (20 mg/ml), and methanol.
Storage :
Store at 4° C
Boiling Point :
1718.78° C at 76 mmHg (Predicted)
Density :
1.83 g/cm3 (Predicted)
Refractive Index :
n20D 1.78 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
SY0525000
PubChem CID :
72511
MDL Number :
MFCD00131846
SMILES :
CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)O[C@H]3[C@@]([C@H]([C@@H]([C@@H](O3)CO)O)O)(C)O[C@H]4[C@@H]([C@]([C@H](C(O4)CO)O)(C(=O)N)O)O)C(=O)NC(C)C(C(C)C(=O)NC(C(=O)C)C(=O)NCCC5=NC(CS5)C6=NC(=CS6)C(=O)N)O

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Certificate of Analysis

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What is the shipping temperature of this product?

Asked by: hawkeye11
This chemical, Phleomycin (CAS 11006-33-0), ships ambient.
Answered by: Chemical Support 1
Date published: 2017-03-24
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Rated 5 out of 5 by from Various publications cite the use of phleomycin Various publications cite the use of phleomycin as a DNA degrading antibiotic. -SCBT Publication Review
Date published: 2015-05-03
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