Phenylbutazone Phenylbutazone is an inhibitor of Cox (cyclooxygenase) that is also a substrate for peroxidation by Cox.

Phenylbutazone  (CAS 50-33-9)

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Application: An inhibitor of Cox
CAS Number: 50-33-9
Purity: ≥99%
Molecular Weight: 308.38
Molecular Formula: C19H20N2O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Phenylbutazone sc-204843 5 g $30.00

Phenylbutazone is a compound of research interest as an anti-inflammatory and anti-proliferative agent. Several studies have investigated Phenylbutazone as an anti-inflammatory agent and its role in mediating prostaglandin synthesis. Phenylbutazone may be of interest regarding research into anti-proliferative effects as well, especially in colorectal cancer studies. In studies with human colon cancer cell lines investigating anti-proliferative capabilities of NSAIDs, Phenylbutazone was noted to have intermediate anti-proliferative potency as compared to other NSAIDs. Phenylbutazone is an inhibitor of Cox (cyclooxygenase) that is also a substrate for peroxidation by Cox.


References

1. Takahashi, M., et al. 1990. Carcinogenesis. 11: 393-395. PMID: 2311181
2. Hixson, L.J., et al. 1994. Cancer Epidemiol. Biomarkers Prev. 3: 433-438. PMID: 7920212
3. Rainsford, K.D. 2007. Subcell. Biochem. 42: 3-27. PMID: 17612044

Physical State :
Solid
Solubility :
Soluble in water (1 mg/ml at 25° C), ethanol (62 mg/ml at 25° C), methanol, DMSO (62 mg/ml at 25° C), and DMF (25 mg/ml).
Storage :
Store at room temperature
Melting Point :
106-108° C (lit.)
Boiling Point :
~424.9° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
IC50 :
Cox-1: IC50 = 3 µM (human); Cyclooxygenase-2: IC50 = 3.79 µM (Canis lupus familiaris); PGH synthase : IC50 = 10 µM; Plasmodium falciparum 3D7: IC50 = 10 µM; Plasmodium falciparum D10: IC50 = 12.59 µM
Ki Data :
CYP2C9: Ki= 19 µM (human); OAT3: Ki= 34.7 µM (human); AZT glucuronidation: Ki= 1.4 mM (human); Codeine glucuronidation: Ki= 1.7 mM
pK Values :
pKa: 4.64 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UQ8225000
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
4781
Merck Index :
14: 7277
MDL Number :
MFCD00005500
EC Number :
200-029-0
Beilstein Registry :
290080
SMILES :
CCCCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3

Download SDS (MSDS)

Certificate of Analysis

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