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Phenidone inhibits both the LO (lipoxygenase) and Cox (cyclooxygenase) pathways, the synthesis of Fos-related antigen protein, and is described as an anti-inflammatory and anti-oxidant compound. Studies indicate that Phenidone decreases the oxidative affects of xanthine/xanthine oxidase, Hydrogen Peroxide (sc-203336), Arachidonic Acid(sc-200770), and Fe2+ ascorbic acid. Mouse cortical research reports that Phenidone weakens oxygen/glucose deprivation-induced neurotoxicity through apoptotic and antioxidant action. Phenidone has been shown to block neurotoxicity induced by kainate, and weakens oxidative stress induced by lipopolysaccharide.
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