Phenidone Phenidone inhibits both the LO (lipoxygenase) and Cox (cyclooxygenase) pathways, the synthesis of Fos-related antigen protein, and is described as an anti-inflammatory and anti-oxidant compound.

Phenidone  (CAS 92-43-3)

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Application: A dual LO (lipoxygenase) and Cox (cyclooxygenase) inhibitor
CAS Number: 92-43-3
Molecular Weight: 162.2
Molecular Formula: C9H10N2O
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Phenidone sc-200508 5 g $30.00

Phenidone inhibits both the LO (lipoxygenase) and Cox (cyclooxygenase) pathways, the synthesis of Fos-related antigen protein, and is described as an anti-inflammatory and anti-oxidant compound. Studies indicate that Phenidone decreases the oxidative affects of xanthine/xanthine oxidase, Hydrogen Peroxide (sc-203336), Arachidonic Acid(sc-200770), and Fe2+ ascorbic acid. Mouse cortical research reports that Phenidone weakens oxygen/glucose deprivation-induced neurotoxicity through apoptotic and antioxidant action. Phenidone has been shown to block neurotoxicity induced by kainate, and weakens oxidative stress induced by lipopolysaccharide.


References

1. Wie, M.B., et al. 1999. Neurosci. Lett. 272: 91-94. PMID: 10507549
2. Kim, H.C., et al. 2000. Brain Res. 874: 15-23. PMID: 10936219
3. Moon, C., et al. 2005. Brain Res. 1035: 206-210. PMID: 15722060
4. Cusan, C., et al. 2006. Curr Drug Discov Technol. 3: 67-73. PMID: 16712464
5. Li, Z., et al. 2008. Neurosci. Lett. 445: 1-6. PMID: 18760329

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (1:10 hot), methanol (0.1 mg/mL), DMSO (75 mg/mL), and ethanol (25 mg/mL).
Storage :
Store at room temperature
Melting Point :
122-123° C
Boiling Point :
304.1° C at 760 mmHg
Density :
1.19 g/cm3
Refractive Index :
n20D 1.58
IC50 :
Dual lipoxygenase: IC50 = 24 µM; cyclooxygenase : IC50 = 11.8 µM
pK Values :
pKa: 9.5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
UQ8750000
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
7090
Merck Index :
14: 7309
MDL Number :
MFCD00003094
EC Number :
202-155-1
Beilstein Registry :
131856
SMILES :
C1CN(NC1=O)C2=CC=CC=C2

Download SDS (MSDS)

Certificate of Analysis

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