PGE1 (Prostaglandin E1) A potent vasodilator, inhibitor of human platelet aggregation, and has been shown to affect PKC and adenylate cyclase - yielding a multitude of physiological implications.

PGE1 (Prostaglandin E1)  (CAS 745-65-3)

PGE1 (Prostaglandin E1) is rated 5.0 out of 5 by 1.
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Synonym: Alprostadil; Edex; Caverject; Muse; Prostin VR
Application: A major prostaglandin that affects protein kinase C (PKC), calcium movement, and adenylate cyclase
CAS Number: 745-65-3
Purity: ≥97%
Molecular Weight: 354.48
Molecular Formula: C20H34O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
PGE1 (Prostaglandin E1) sc-201223 1 mg $22.00
PGE1 (Prostaglandin E1) sc-201223A 10 mg $135.00

Prostaglandin E1 (PGE1) is a major prostaglandin found in human semen that acts as a vasodilator, a fibrinolytic agent, and an inhibitor of platelet aggregation. Additionally, PGE1 has been shown to affect protein kinase C (PKC), calcium movement, and adenylate cyclase yielding a multitude of physiological effects.


References

1. Mai, J., et al. 1980. Prostaglandins. 20: 187-197. PMID: 7413990
2. Speroff, L., et al. 1970. Am. J. Obstet. Gynecol. 107: 1111-1130. PMID: 4914185
3. Rubin, D. and Laposata, M. 1991. J. Biol. Chem. 266: 23618-23623. PMID: 1748640
4. Kloeze, J. 1969. Biochim. Biophys. Acta. 187: 285-292. PMID: 4981666
5. Kurstjens, N.P., et al. 1990. Biochem. Biophys. Res. Commun. 167: 1162-1169. PMID: 1690994
6. Kirtland, S.J. 1988. Prostaglandins Leukot. Essent. Fatty Acids. 32: 165-174. PMID: 2901111

Physical State :
Solid
Solubility :
Soluble in ethanol (5 mg/ml), water, DMSO (~50 mg/ml), DMF (~50 mg/ml), PBS(pH 7.2) (~1.67 mg/ml), THF, acetone (10 g/l) at 25° C, ethyl acetate, and methanol.
Storage :
Store at -20° C
Melting Point :
114-115° C
Boiling Point :
529.28° C at 760 mmHg
Density :
~1.13 g/cm3 (Predicted)
Refractive Index :
n20D ~1.55 (Predicted)
Optical Activity :
α20/D -61.6°, c = 0.56% in Tetrahydrofuran for 578 nm spectral line
IC50 :
ADP-induced platelet aggregation: IC50 = 40 nM (human); Oryctolagus cuniculus: IC50 = 0.01 ug/mL; Prostanoid IP receptor: IC50 = 1.4 µM (human); Prostanoid EP4 receptor: EC5050 = 2.5 nM (mouse)
Ki Data :
EP3 receptors: Ki= 1.1 nM (mouse); EP4 receptors: Ki= 2.6 nM (mouse); EP1 receptors: Ki= 36 nM (mouse); EP2 receptors: Ki= 10 nM (mouse); IP receptors: Ki= 33 nM (mouse)
pK Values :
pKa: 4.77 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
GY4569800
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
5280723
Merck Index :
14: 7876
MDL Number :
MFCD00077860
EC Number :
212-017-2
Beilstein Registry :
5294062
SMILES :
CCCCC[C@@H](/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1CCCCCCC(=O)O)O)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Jin Jin, et al. (PubMed ID 25928762) explored the preventative effects afforded by Prostaglandin E1 (PGE1) treatment of rabbits with CCl4-induced liver fibrosis. Found that PGE1 when used in conjunction with olive oil, did prevent the development of liver fibrosis after TACE. -SCBT Publication Review
Date published: 2015-06-27
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