Prostaglandin E1 (PGE1) is a major prostaglandin found in human semen that acts as a vasodilator, a fibrinolytic agent, and an inhibitor of platelet aggregation. Additionally, PGE1 has been shown to affect protein kinase C (PKC), calcium movement, and adenylate cyclase yielding a multitude of physiological effects.
1. Mai, J., et al. 1980. Prostaglandins. 20: 187-197. PMID: 7413990 2. Speroff, L., et al. 1970. Am. J. Obstet. Gynecol. 107: 1111-1130. PMID: 4914185 3. Rubin, D. and Laposata, M. 1991. J. Biol. Chem. 266: 23618-23623. PMID: 1748640 4. Kloeze, J. 1969. Biochim. Biophys. Acta. 187: 285-292. PMID: 4981666 5. Kurstjens, N.P., et al. 1990. Biochem. Biophys. Res. Commun. 167: 1162-1169. PMID: 1690994 6. Kirtland, S.J. 1988. Prostaglandins Leukot. Essent. Fatty Acids. 32: 165-174. PMID: 2901111
Soluble in ethanol (5 mg/ml), water, DMSO (~50 mg/ml), DMF (~50 mg/ml), PBS(pH 7.2) (~1.67 mg/ml), THF, acetone (10 g/l) at 25° C, ethyl acetate, and methanol.
Store at -20° C
529.28° C at 760 mmHg
~1.13 g/cm3 (Predicted)
n20D ~1.55 (Predicted)
α20/D -61.6°, c = 0.56% in Tetrahydrofuran for 578 nm spectral line
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Rated 5 out of
JinJin, et al. (PubMed ID 25928762) explored the preventative effects afforded by Prostaglandin E1 (PGE1) treatment of rabbits with CCl4-induced liver fibrosis. Found that PGE1 when used in conjunction with olive oil, did prevent the development of liver fibrosis after TACE. -SCBT Publication Review
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