PGE1 (Prostaglandin E1) A major prostaglandin that affects protein kinase C (PKC), calcium movement, and adenylate cyclase

PGE1 (Prostaglandin E1)  (CAS 745-65-3)

PGE1 (Prostaglandin E1) is rated 5.0 out of 5 by 2.
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Synonym: Alprostadil; Edex; Caverject; Muse; Prostin VR
Application: A major prostaglandin that affects protein kinase C (PKC), calcium movement, and adenylate cyclase
CAS Number: 745-65-3
Purity: ≥97%
Molecular Weight: 354.48
Molecular Formula: C20H34O5
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
PGE1 (Prostaglandin E1) sc-201223 1 mg $22.00
PGE1 (Prostaglandin E1) sc-201223A 10 mg $135.00

Prostaglandin E1 (PGE1) is a major prostaglandin found in human semen that acts as a vasodilator, a fibrinolytic agent, and an inhibitor of platelet aggregation. Additionally, PGE1 has been shown to affect protein kinase C (PKC), calcium movement, and adenylate cyclase yielding a multitude of physiological effects.


References

1. Mai, J., et al. 1980. Prostaglandins. 20: 187-197. PMID: 7413990
2. Speroff, L., et al. 1970. Am. J. Obstet. Gynecol. 107: 1111-1130. PMID: 4914185
3. Rubin, D. and Laposata, M. 1991. J. Biol. Chem. 266: 23618-23623. PMID: 1748640
4. Kloeze, J. 1969. Biochim. Biophys. Acta. 187: 285-292. PMID: 4981666
5. Kurstjens, N.P., et al. 1990. Biochem. Biophys. Res. Commun. 167: 1162-1169. PMID: 1690994
6. Kirtland, S.J. 1988. Prostaglandins Leukot. Essent. Fatty Acids. 32: 165-174. PMID: 2901111

Physical State :
Solid
Solubility :
Soluble in ethanol (5 mg/ml), water, DMSO (~50 mg/ml), DMF (~50 mg/ml), PBS(pH 7.2) (~1.67 mg/ml), THF, acetone (10 g/l) at 25° C, ethyl acetate, and methanol.
Storage :
Store at -20° C
Melting Point :
114-115° C
Boiling Point :
529.28° C at 760 mmHg
Density :
~1.13 g/cm3 (Predicted)
Refractive Index :
n20D ~1.55 (Predicted)
Optical Activity :
α20/D -61.6°, c = 0.56% in Tetrahydrofuran for 578 nm spectral line
IC50 :
ADP-induced platelet aggregation: IC50 = 40 nM (human); Oryctolagus cuniculus: IC50 = 0.01 ug/mL; Prostanoid IP receptor: IC50 = 1.4 µM (human); Prostanoid EP4 receptor: EC5050 = 2.5 nM (mouse)
Ki Data :
EP3 receptors: Ki= 1.1 nM (mouse); EP4 receptors: Ki= 2.6 nM (mouse); EP1 receptors: Ki= 36 nM (mouse); EP2 receptors: Ki= 10 nM (mouse); IP receptors: Ki= 33 nM (mouse)
pK Values :
pKa: 4.77 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
GY4569800
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
5280723
Merck Index :
14: 7876
MDL Number :
MFCD00077860
EC Number :
212-017-2
Beilstein Registry :
5294062
SMILES :
CCCCC[C@@H](/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1CCCCCCC(=O)O)O)O

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Certificate of Analysis

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Podría indicarme cómo mezclar 10 mg de PGE1 (Prostaglandin E1) sc-201223A utilizando como disolvente DMSO (Sterile Filtered) sc-359032?

Asked by: LACC
Este producto es soluble en DMSO a ~ 50 mg / ml. This product is soluble in DMSO at ~50mg/ml.
Answered by: Tech Service 3
Date published: 2017-04-07

This chemical should dissolve completely in solution, but my sample consistently has particulate in the solution that won't dissolve.  What else is in the vial that might be causing that impurity?

Asked by: two2igm05
Thank you for your question. PGE1 (Prostaglandin E1), sc-201223, is slightly soluble in water. It dissolves in phosphate buffer at pH 7.4-8.0, but the solvent you used seems like an acidic aqueous buffer and it should be slightly soluble.
Answered by: Chemical Support 4
Date published: 2017-03-02

Once in solution, how long does this compound remain stable and active for?

Asked by: two2igm05
The product ca be stored for up to 3 years at -20℃ as a powder, or up to 2 years at -80℃ in solvent.
Answered by: Tech Service 4
Date published: 2016-12-17
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Rated 5 out of 5 by from Producto de muy buena calidad! Excelente calidad de producto y servicio al cliente.
Date published: 2017-01-30
Rated 5 out of 5 by from Jin Jin, et al. (PubMed ID 25928762) explored the preventative effects afforded by Prostaglandin E1 (PGE1) treatment of rabbits with CCl4-induced liver fibrosis. Found that PGE1 when used in conjunction with olive oil, did prevent the development of liver fibrosis after TACE. -SCBT Publication Review
Date published: 2015-06-27
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