Pepstatin A An inhibitor of HIV-1 and aspartic proteases

Pepstatin A (CAS 26305-03-3)

Pepstatin A | CAS 26305-03-3 is rated 4.8 out of 5 by 4.
  • y_2019, m_4, d_21, h_2
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_4
  • loc_en_US, sid_45036, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 258ms
  • REVIEWS, PRODUCT
Synonym: Pepstatin; Isoval-Val-Val-Sta-Ala-Sta
Application: An inhibitor of HIV-1 and aspartic proteases
CAS Number: 26305-03-3
Purity: >90%
Molecular Weight: 685.89
Molecular Formula: C34H63N5O9
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Pepstatin A inhibits the aspartic proteases cathepsin D, pepsin, and renin. Additionally, it suppresses p53-dependent apoptosis in lymphoid cells as well as TNFα-induced apoptosis in U937 cells. Pepstatin A also efficiently inhibits HIV-1 protease and Fcγ receptor induction by IFN-γ.


References

1. Umezawa, H., et al. 1970. J. Antibiot. 23: 259-262. PMID: 4912600
2. Deiss, L.P., et al. 1996. EMBO J. 15: 3861-3870. PMID: 8670891
3. Wu, G.S., et al. 1998. Oncogene. 16: 2177-2183. PMID: 9619826
4. Athanassakis, I., et al. 2000. Cell. Immunol. 199: 81-88. PMID: 10698617
5. Farías, M.E., et al. 2000. FEMS Microbiol. Lett. 185: 263-266. PMID: 10754258

Usage :
Effective working concentration is a 1 μM solution, stable for at least 1 day at room temperature.
Physical State :
Solid
Sequence :
Isovaleryl-Val-Val-Sta-Ala-Sta
Solubility :
Soluble in 10% (v/v) acetic acid in methanol (9:1 methanol:acetic acid) (1 mg/ml), ethanol (1-2 mg/ml with heat up to 60° C), DMSO (5 mg/ml), methanol (1 mg/ml), and acetic acid. Insoluble in benzene, chloroform, water, 1 M NaOH, and ether.
Storage :
Store at -20° C
Melting Point :
233° C (dec.)
Boiling Point :
~997.6° C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.50 (Predicted)
Optical Activity :
α20/D -90.0°±5°, c = 0.5 in MeOH
pK Values :
pKa: 4.17 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
SC6155000
PubChem CID :
5478883
Merck Index :
14: 7147
MDL Number :
MFCD00060740
EC Number :
247-600-0
Beilstein Registry :
2201362
SMILES :
C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)O)O)NC(=O)C[C@@H]([C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)CC(C)C)O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Pepstatin A  Product Citations

See how others have used Pepstatin A. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 16 total

PMID: # 26730950  Markosyan, RM. et al. 2016. PLoS pathogens. 12: e1005373.

PMID: # 28105029  Welsby, I. et al. 2016. Front Immunol. 7: 663.

PMID: # 27297104  Okoro, EU. et al. 2016. Biochemical and biophysical research communications.

PMID: # 26935990  Wang, W. et al. 2016. Scientific reports. 6: 22550.

PMID: # 25042057  Kong, L. et al. 2015. Arch. Insect Biochem. Physiol. 88: 64-84.

PMID: # 26163003  Gorojod, RM. et al. 2015. Free Radic. Biol. Med. 87: 237-51.

PMID: # 24726834  Granato, M. et al. 2014. Biochimica et biophysica acta. 1843: 1348-55.

PMID: # 24880896  Valcheva, P. et al. 2014. Atherosclerosis. 235: 247-55.

PMID: # 25535899  Katona, BW. et al. 2014. Cancer Biol. Ther. 15: 1677-87.

PMID: # 24859454  Zhou, X. et al. 2014. Journal of hepatology. 61: 746-54.

Citations 1 to 10 of 16 total

Is this Pepstatin A  (CAS 26305-03-3) of microbial origin or synthetic ?

Asked by: Rahulgaur
Thank you for inquiring with us. Our Pepstatin A sc-45036 is synthetic in origin. Please contact Technical Service by phone, (800)-457-3801 option 2, email <scbt@scbt.com>, or by live chat directly on our website, www.scbt.com if you have any further questions.
Answered by: Technical Service
Date published: 2017-07-04

Is this compound cell permeable?

Asked by: Jz28sail
Thank you for your question. sc-45036, Pepstatin A is not cell permeable. We recommend sc-222147, Pepstatin A Methyl Ester as a cell permeable alternative product (https://www.scbt.com/scbt/product/pepstatin-a-methyl-ester).
Answered by: Chemical Support 5
Date published: 2017-04-07
  • y_2019, m_4, d_21, h_2CST
  • bvseo_bulk, prod_bvqa, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_2
  • loc_en_US, sid_45036, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 99ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from It works fine I employed this inhibitor to demonstrate the involvement of Cathepsin D in cell death. Pepstatin A was dissolved in DMSO. For assays, cells were incubated with Pepstatin A 10uM 1h prior to treatment.
Date published: 2017-01-26
Rated 5 out of 5 by from This drug exerts its function pretty well This drug exerts its function pretty well in autophagy induction. Published data
Date published: 2015-11-06
Rated 4 out of 5 by from Works well for insect disections Works well for insect disections.
Date published: 2015-11-02
Rated 5 out of 5 by from Wang Wang, Y. et al. (PubMed 26258792) found that Pepstatin A, an inhibitor of aspartic proteases: cathepsin D, pepsin, and renin, relieved citreoviridin-induced apoptosis. -SCBT Publication Review
Date published: 2015-01-24
  • y_2019, m_4, d_21, h_2
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_4
  • loc_en_US, sid_45036, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 228ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.