Pepstatin AAn inhibitor of HIV-1 and aspartic proteases
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Pepstatin A (CAS 26305-03-3)

Pepstatin A | CAS 26305-03-3 is rated 4.8 out of 5 by 4.
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See product citations (22)
Synonym: Pepstatin; Isoval-Val-Val-Sta-Ala-Sta
Application: An inhibitor of HIV-1 and aspartic proteases
CAS Number: 26305-03-3
Purity: >90%
Molecular Weight: 685.89
Molecular Formula: C34H63N5O9
* Refer to Certificate of Analysis for lot specific data (including water content).
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Pepstatin A inhibits the aspartic proteases cathepsin D, pepsin, and renin. Additionally, it suppresses p53-dependent apoptosis in lymphoid cells as well as TNFα-induced apoptosis in U937 cells. Pepstatin A also efficiently inhibits HIV-1 protease and Fcγ receptor induction by IFN-γ.


References

1. Umezawa, H., et al. 1970. J. Antibiot. 23: 259-262. PMID: 4912600
2. Deiss, L.P., et al. 1996. EMBO J. 15: 3861-3870. PMID: 8670891
3. Wu, G.S., et al. 1998. Oncogene. 16: 2177-2183. PMID: 9619826
4. Athanassakis, I., et al. 2000. Cell. Immunol. 199: 81-88. PMID: 10698617
5. Farías, M.E., et al. 2000. FEMS Microbiol. Lett. 185: 263-266. PMID: 10754258

Usage :
Effective working concentration is a 1 μM solution, stable for at least 1 day at room temperature.
Physical State :
Solid
Sequence :
Isovaleryl-Val-Val-Sta-Ala-Sta
Solubility :
Soluble in 10% (v/v) acetic acid in methanol (9:1 methanol:acetic acid) (1 mg/ml), ethanol (1-2 mg/ml with heat up to 60° C), DMSO (5 mg/ml), methanol (1 mg/ml), and acetic acid. Insoluble in benzene, chloroform, water, 1 M NaOH, and ether.
Storage :
Store at -20° C
Melting Point :
233° C (dec.)
Boiling Point :
~997.6° C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.50 (Predicted)
Optical Activity :
α20/D -90.0°±5°, c = 0.5 in MeOH
pK Values :
pKa: 4.17 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
SC6155000
PubChem CID :
5478883
Merck Index :
14: 7147
MDL Number :
MFCD00060740
EC Number :
247-600-0
Beilstein Registry :
2201362
SMILES :
C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)O)O)NC(=O)C[C@@H]([C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)CC(C)C)O

Download SDS (MSDS)

Certificate of Analysis

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Pepstatin A  Product Citations

See how others have used Pepstatin A. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 22 total

PMID: # 31123703  Di Rienzo, M.|Antonioli, M.|Fusco, C.|Liu, Y.|Mari, M.|Orhon, I.|Refolo, G.|Germani, F.|Corazzari, M.|Romagnoli, A.|Ciccosanti, F.|Mandriani, B.|Pellico, MT.|De La Torre, R.|Ding, H.|Dentice, M.|Neri, M.|Ferlini, A.|Reggiori, F.|Kulesz-Martin, M.|Piacentini, M.|Merla, G.|Fimia, GM.| et al. 2019. Sci Adv. 5: eaau8857.

PMID: # 30270174  Risi, C.|Belknap, B.|Forgacs-Lonart, E.|Harris, SP.|Schröder, GF.|White, HD.|Galkin, VE.| et al. 2018. Structure. 26: 1604-1611.e4.

PMID: # 30387075  Prado Spalm, FH. et al. 2018. Mol. Neurobiol.

PMID: # 28475412  Yin, Y.|Dang, W.|Zhou, X.|Xu, L.|Wang, W.|Cao, W.|Chen, S.|Su, J.|Cai, X.|Xiao, S.|Peppelenbosch, MP.|Pan, Q.| et al. 2018. Virulence. 9: 83-98.

PMID: # 29859188  Lin, YM. et al. 2018. Biochem. Biophys. Res. Commun. 503: 157-164.

PMID: # 27760898  Mitsui, T.|Ishida, M.|Izawa, M.|Arita, J.| et al. 2017. Endocr. J. 64: 103-115.

PMID: # 26730950  Markosyan, RM. et al. 2016. PLoS pathogens. 12: e1005373.

PMID: # 28105029  Welsby, I. et al. 2016. Front Immunol. 7: 663.

PMID: # 27297104  Okoro, EU. et al. 2016. Biochemical and biophysical research communications.

PMID: # 26935990  Wang, W. et al. 2016. Scientific reports. 6: 22550.

Citations 1 to 10 of 22 total

Is this Pepstatin A  (CAS 26305-03-3) of microbial origin or synthetic ?

Asked by: Rahulgaur
Thank you for inquiring with us. Our Pepstatin A sc-45036 is synthetic in origin. Please contact Technical Service by phone, (800)-457-3801 option 2, email <scbt@scbt.com>, or by live chat directly on our website, www.scbt.com if you have any further questions.
Answered by: Technical Service
Date published: 2019-06-16

Is this compound cell permeable?

Asked by: Jz28sail
Thank you for your question. sc-45036, Pepstatin A is not cell permeable. We recommend sc-222147, Pepstatin A Methyl Ester as a cell permeable alternative product (https://www.scbt.com/scbt/product/pepstatin-a-methyl-ester).
Answered by: Chemical Support 5
Date published: 2017-04-07
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Rated 5 out of 5 by from It works fine I employed this inhibitor to demonstrate the involvement of Cathepsin D in cell death. Pepstatin A was dissolved in DMSO. For assays, cells were incubated with Pepstatin A 10uM 1h prior to treatment.
Date published: 2017-01-26
Rated 5 out of 5 by from This drug exerts its function pretty well This drug exerts its function pretty well in autophagy induction. Published data
Date published: 2015-11-06
Rated 4 out of 5 by from Works well for insect disections Works well for insect disections.
Date published: 2015-11-02
Rated 5 out of 5 by from Wang Wang, Y. et al. (PubMed 26258792) found that Pepstatin A, an inhibitor of aspartic proteases: cathepsin D, pepsin, and renin, relieved citreoviridin-induced apoptosis. -SCBT Publication Review
Date published: 2015-01-24
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