Pepstatin A inhibits the aspartic proteases cathepsin D, pepsin, and renin. Additionally, it suppresses p53-dependent apoptosis in lymphoid cells as well as TNFα-induced apoptosis in U937 cells. Pepstatin A also efficiently inhibits HIV-1 protease and Fcγ receptor induction by IFN-γ.
1. Umezawa, H., et al. 1970. J. Antibiot. 23: 259-262. PMID: 4912600 2. Deiss, L.P., et al. 1996. EMBO J. 15: 3861-3870. PMID: 8670891 3. Wu, G.S., et al. 1998. Oncogene. 16: 2177-2183. PMID: 9619826 4. Athanassakis, I., et al. 2000. Cell. Immunol. 199: 81-88. PMID: 10698617 5. Farías, M.E., et al. 2000. FEMS Microbiol. Lett. 185: 263-266. PMID: 10754258
Effective working concentration is a 1 μM solution, stable for at least 1 day at room temperature.
Soluble in 10% (v/v) acetic acid in methanol (9:1 methanol:acetic acid) (1 mg/ml), ethanol (1-2 mg/ml with heat up to 60° C), DMSO (5 mg/ml), methanol (1 mg/ml), and acetic acid. Insoluble in benzene, chloroform, water, 1 M NaOH, and ether.
Store at -20° C
233° C (dec.)
~997.6° C at 760 mmHg (Predicted)
~1.1 g/cm3 (Predicted)
n20D 1.50 (Predicted)
α20/D -90.0°±5°, c = 0.5 in MeOH
pKa: 4.17 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Is this Pepstatin A (CAS 26305-03-3) of microbial origin or synthetic ?
Asked by: Rahulgaur
Thank you for inquiring with us. Our Pepstatin A sc-45036 is synthetic in origin. Please contact Technical Service by phone, (800)-457-3801 option 2, email <email@example.com>, or by live chat directly on our website, www.scbt.com if you have any further questions.
Answered by: Technical Service
Date published: 2017-07-04
Is this compound cell permeable?
Asked by: Jz28sail
Thank you for your question. sc-45036, Pepstatin A is not cell permeable. We recommend sc-222147, Pepstatin A Methyl Ester as a cell permeable alternative product (https://www.scbt.com/scbt/product/pepstatin-a-methyl-ester).
Rated 5 out of
It works fineI employed this inhibitor to demonstrate the involvement of Cathepsin D in cell death. Pepstatin A was dissolved in DMSO. For assays, cells were incubated with Pepstatin A 10uM 1h prior to treatment.
Date published: 2017-01-26
Rated 5 out of
This drug exerts its function pretty wellThis drug exerts its function pretty well in autophagy induction. Published data
Date published: 2015-11-06
Rated 4 out of
Works well for insect disectionsWorks well for insect disections.
Date published: 2015-11-02
Rated 5 out of
WangWang, Y. et al. (PubMed 26258792) found that Pepstatin A, an inhibitor of aspartic proteases: cathepsin D, pepsin, and renin, relieved citreoviridin-induced apoptosis. -SCBT Publication Review
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