Penicillin G procaine A combination of Penicillin G and Procaine

Penicillin G procaine (CAS 6130-64-9)

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Synonym: Duracillin; Bicillin C-R; Aquacilina
Application: A combination of Penicillin G and Procaine
CAS Number: 6130-64-9
Purity: ≥98%
Molecular Weight: 570.70
Molecular Formula: C29H38N4O6S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Penicillin G procaine is a combination of penicillin G and procaine. Penicillin G is a hydrophobic, β-lactam antibiotic produced by Penicillium spp.. As an antibiotic, penicillin G is noted to posses effectiveness mainly against gram-positive organisms. Some gram-negative organisms such as Neiserria gonorrhoeae and Neiserria meningitidis are also reported to be susceptible to penicillin G. Penicillin G is also known as benzylpenicillin and contains a 6′ phenylacetyl side chain. In acid aqueous solutions, penicillin is reported to decompose into penillic acid and penilloic acid.
Procaine is a noted sodium channel blocker with a variety of inhibitory effects. In skeletal muscle, procaine has been reported to inhibit calcium-induced calcium release (CICR). Procaine is also noted to act as a DNA methylation inhibitor and to cause demethylation and reactivation of methylation-silenced genes such as RARβ and GSTP1. WIF-1 is noted to be reactivated in a cancer cell line and to downregulate the Wnt canonical pathway. In studies utilizing a neuroblastoma cell line (SHEP), procaine is reported to induce neuronal apoptosis in a manner correlated with lipid solubility of the compound. In an adult mouse muscle cell line (HEK293), the presence of procaine is reported to potently inhibit AChR (nicotinic acetylcholine receptors).

Penicillin G is also available alone (sc-344973) and in salt forms such as Penicillin G sodium (sc-257971) and penicillin G potassium (sc-255411). Procaine is available alone (sc-296134) and in its salt form, procaine HCl (sc-250776).


References

1. Schwartz, M.A. 1965. J Pharm Sci. 54: 472-473. PMID: 14301592
2. Demain, A.L. 1991. Proc. Natl. Sci. Counc. Repub. China B. 15: 251-265. PMID: 1815263
3. Werdehausen, R., et al. 2009. Br J Anaesth. 103: 711-718. PMID: 19700777
4. Livermore, D.M. 2009. Curr. Protein Pept. Sci. 10: 397-400. PMID: 19538149
5. Gao, Z., et al. 2009. Oncol. Rep. 22: 1479-1484. PMID: 19885602
6. Endo, M. 2009. Physiol. Rev. 89: 1153-1176. PMID: 19789379
7. Wang, H., et al. 2010. Eur. J. Pharmacol. 630: 29-33. PMID: 20045405
8. Gal, R. and Libersat, F. 2010. PLoS ONE. 5: e10019. PMID: 20383324

Physical State :
Solid
Solubility :
Soluble in water (6.8 mg/ml at 28° C), alcohol (1:30), DMSO, methanol (>20 mg/ml at 28° C), and isopropanol (6.5 mg/ml at 28° C).
Storage :
Store at 4° C
Melting Point :
106-110° C (dec.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
MDL Number :
MFCD00150771
EC Number :
200-205-7
SMILES :
CCN(CC)CCOC(=O)C1=CC=C(C=C1)N.CC1(C(N2C(S1)C(C2=O)NC(=O)CC3=CC=CC=C3)C(=O)O)C

Download SDS (MSDS)

Certificate of Analysis

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Ask a question...procaine can it treat the respiratory infections???

Asked by: shida
Thank you for your question. Our products are produced and sold exclusively for research purposes and are not suited or specified for use as therapeutics.
Answered by: SCBT Heidelberg Support
Date published: 2018-12-29

 molecular weight penicillin g procaine sodium 

Asked by: naela
Thank you for your question. This chemical, Penicillin G procaine (CAS 6130-64-9) has a molecular weight of 570.70.
Answered by: Technical Support
Date published: 2016-12-21
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