Penicillin G potassium salt A β-lactam antibiotic

Penicillin G potassium salt (CAS 113-98-4)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 63ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: Benzylpenicillin Potassium Salt
Application: A β-lactam antibiotic
CAS Number: 113-98-4
Molecular Weight: 372.48
Molecular Formula: C16H17KN2O4S
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Penicillin G potassium salt is a salt of Penicillin G. Penicillin G is a hydrophobic, β-lactam antibiotic produced by Penicillium spp. As an antibiotic, Penicillin G is noted to posses effectiveness mainly against gram-positive organisms. Some gram-negative organisms such as Neiserria gonorrhoeae and Neiserria meningitidis are also reported to be susceptible to Penicillin G. Penicillin G is also known as benzylpenicillin and contains a 6′ phenylacetyl side chain. In acid aqueous solutions, Penicillin is reported to decompose into penillic acid and penilloic acid. Penicillin G is also available as a non-salt (sc-344973) and in salt forms such as Penicillin G sodium (sc-257971).


References

1. Schwartz, M.A. 1965. J Pharm Sci. 54: 472-473. PMID: 14301592
2. Demain, A.L. 1991. Proc. Natl. Sci. Counc. Repub. China B. 15: 251-265. PMID: 1815263
3. Livermore, D.M. 2009. Curr. Protein Pept. Sci. 10: 397-400. PMID: 19538149

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (100 mg/ml), methanol, ethanol (sparingly), and alcohol. Insoluble in chloroform.
Storage :
Store at 4° C
Melting Point :
214-217° C (lit.)
Density :
1.36 g/cm3
Refractive Index :
n20D ~1.66 (Predicted)
Optical Activity :
α20/D 285°±15°, c = 1 in water
IC50 :
Penicillin-binding protein 1A: IC50 = 0.002 µg/ml (Streptococcus pneumoniae serotype 4 ); Penicillin-binding protein 2B: IC50 = 0.007 µg/ml (Streptococcus pneumoniae serotype 4 ); Penicillin-binding protein 2x: IC50 = 0.007 µg/ml (Streptococcus pneumoniae serotype 4 ); Bacillus subtilis: IC50 = 1.56 µg/ml; Staphylococcus aureus: IC50 = 1.56 µg/ml
Ki Data :
Beta-lactamase TEM: Ki= 20 µM (Escherichia coli); Solute carrier family 22 member 8: Ki= 52.8 µM (rat); OAT3: Ki= 97.6 µM (human); Solute carrier family 22 member 6: Ki= 328 µM (mouse); Solute carrier family 22 member 6: Ki= 418 µM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
XH9700000
PubChem CID :
23664709
Merck Index :
14: 7094
MDL Number :
MFCD00036193
EC Number :
204-038-0
Beilstein Registry :
3832841
SMILES :
CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)CC3=CC=CC=C3)C(=O)[O-])C.[K+]

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 75ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 5ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.