Penicillamine An exogenous NOS modulator and an antirheumatic and chelating agent used for Wilson's disease

Penicillamine (CAS 52-67-5)

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Synonym: Cuprimine; 3-Mercapto-D-valine; Mercaptovaline; D-Penicillamine
Application: An exogenous NOS modulator and an antirheumatic and chelating agent used for Wilson's disease
CAS Number: 52-67-5
Purity: ≥99%
Molecular Weight: 149.21
Molecular Formula: C5H11NO2S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Penicillamine is an exogenous NOS modulator, found to inhibit urease activity.


References

1. Chen, J X., et al., 2001. Nitric oxide donors regulate nitric oxide synthase in bovine pulmonary artery endothelium. Journal of cellular physiology. 186(1): 116-23. PMID: 11147806
2. Sissons, C H., et al., 2000. Suppression of urease levels in Streptococcus salivarius by cysteine, related compounds and by sulfide. Oral microbiology and immunology. 15(5): 317-24. PMID: 11154424

Physical State :
Solid
Solubility :
Soluble in water (30 mg/ml at 25° C), ethanol (<1 mg/ml at 25° C), methanol, and DMSO (<1 mg/ml at 25° C).
Storage :
Store at 4° C
Melting Point :
210° C (lit.)(dec.)
Boiling Point :
~251.8° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.53 (Predicted)
Optical Activity :
α20/D -63°, c = 1 in 1N NaOH; α20/D -65°, c = 5 in 1M NaOH, on dry
IC50 :
ADMET: IC50 = >30 µM; Succinyl-diaminopimelate desuccinylase: IC50 = 50 µM (Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd))
pK Values :
pKa: 2.13 (Predicted), pKb: 11.64 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
YV9425000
PubChem CID :
5852
Merck Index :
14: 7088
MDL Number :
MFCD00064302
EC Number :
200-148-8
Beilstein Registry :
1722375
SMILES :
CC(C)([C@H](C(=O)O)N)S

Download SDS (MSDS)

Certificate of Analysis

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