Additional PEA Antibodies including
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Several members of the Ets gene family are known to encode sequence-specific DNA binding proteins. These include mouse PU.1, mouse and human Ets-1, Drosophila E74, chicken and human Ets-2 and rat GABP-a. Each of these proteins recognizes similar motifs in DNA that share a centrally located 5′-GGAA-3′ element. For instance, PEA3 binds the motif 5′-AGGAAG-3′ (the PEA-3 motif), but does not bind to the sequence 5′-AGGAAC-3′, recognized by PU.1, although PU.1 binds equally well to both sequences. It appears that all of the Ets proteins recognize the same central core sequence but that each protein interacts with unique sequences that flank this core. PEA3 is expressed at readily detectable levels in cells of epithelial and fibroblastic origin but is not expressed in hematopoietic cells. This is in contrast to other members of the Ets gene family, such as Ets-1, Ets-2 and Fli-1, each of which is expressed primarily in cells of hematopoietic origin.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PMID: # 26238631 Kherrouche, Z. et al. 2015. PEA3 transcription factors are downstream effectors of Met signaling involved in migration and invasiveness of Met-addicted tumor cells. Mol Oncol. 9: 1852-67.
PMID: # 24913817 Liclican, EL. et al. 2014. Loss of miR125a expression in a model of K-ras-dependent pulmonary premalignancy. Cancer Prev Res (Phila). 7: 845-55.
PMID: # 24260201 Li, S. et al. 2013. Requirement of PEA3 for transcriptional activation of FAK gene in tumor metastasis. PloS one. 8: e79336.
PMID: # 22075993 Wollenick, K. et al. 2012. Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling. Nucleic Acids Res.. 40: 1928-43.
PMID: # 22610349 Xu, B. et al. 2012. Molecular mechanisms of MMP9 overexpression and its role in emphysema pathogenesis of Smad3-deficient mice. Am. J. Physiol. Lung Cell Mol. Physiol.. 303: L89-96.
PMID: # 21266854 Chen, Y. et al. 2011. ERβ and PEA3 co-activate IL-8 expression and promote the invasion of breast cancer cells. Cancer Biol. Ther.. 11: 497-511.
PMID: # 21613609 Huang, WY. et al. 2011. Smad2 and PEA3 cooperatively regulate transcription of response gene to complement 32 in TGF-β-induced smooth muscle cell differentiation of neural crest cells. Am. J. Physiol., Cell Physiol.. 301: C499-C506.
PMID: # 21778330 Euhus, D. et al. 2011. Tamoxifen downregulates ets oncogene family members ETV4 and ETV5 in benign breast tissue: implications for durable risk reduction. Cancer Prev Res (Phila). 4: 1852-1862.
PMID: # 21673681 Keld, R. et al. 2011. PEA3/ETV4-related transcription factors coupled with active ERK signalling are associated with poor prognosis in gastric adenocarcinoma. Br. J. Cancer. 105: 124-30.
PMID: # 21679465 Clementz, AG. et al. 2011. NOTCH-1 and NOTCH-4 are novel gene targets of PEA3 in breast cancer: novel therapeutic implications. Breast Cancer Res.. 13: -.
When should the TransCruz reagent sc-113 X be used instead of the standard form sc-113?
Asked by: jenni
We recommend using the TransCruz reagent form when performing ChIP or GelShift assays. This form can also be used in other applications such as Western Blot or IHC, but the dilution should be adjusted by a factor of 10 to account for the higher original concentration.
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