PD 153035 Hydrochloride PD 153035 Hydrochloride is an extremely potent inhibitor of EGFR (epidermal growth factor receptor) tyrosine kinase

PD 153035 Hydrochloride  (CAS 183322-45-4)

PD 153035 Hydrochloride is rated 5.0 out of 5 by 1.
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Application: A potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase
CAS Number: 183322-45-4
Purity: ≥99%
Molecular Weight: 396.67
Molecular Formula: C16H14BrN3O2 HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
PD 153035 Hydrochloride sc-205963 10 mg $125.00
PD 153035 Hydrochloride sc-205963A 50 mg $525.00

PD 153035 Hydrochloride is an extremely potent inhibitor of EGFR (epidermal growth factor receptor) tyrosine kinase (IC50 = 25 pM). Only inhibits other purified tyrosine kinases at micromolar or higher concentrations.


References

1. Fry, D.W., et al. 1994. Science. 265: 1093-1095. PMID: 8066447
2. Bridges, A.J., et al. 1996. J. Med. Chem. 39: 267-276. PMID: 8568816
3. Bos, M., et al. 1997. Clin. Cancer Res. 3: 2099-2106. PMID: 9815602

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mM) with gentle warming, water ( <1 mg/mL at 25° C), and ethanol ( <1 mg/mL at 25° C).
Storage :
Store at room temperature
Boiling Point :
472.1° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
EGFR: IC50 = 0.025 nM (human); ErbB-4: IC50 = 49 nM (human); Neu: IC50 = 143 nM (human); MCF7: IC50 = 1613 nM (human)
Ki Data :
EGFR: Ki= 0.006 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
11246488
MDL Number :
MFCD01074805
SMILES :
COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Br)OC.Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Liu W; et al Liu W; et al. (PubMed ID: 22735833) determined that PD 153035 Hydrochloride inhibited EGFR and ERK phosphorylation induced by EGF. -SCBT Publication Review
Date published: 2015-01-02
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