PD 153035 Hydrochloride is an extremely potent inhibitor of EGFR (epidermal growth factor receptor) tyrosine kinase (IC50 = 25 pM). Only inhibits other purified tyrosine kinases at micromolar or higher concentrations.
1. Fry, D.W., et al. 1994. Science. 265: 1093-1095. PMID: 8066447 2. Bridges, A.J., et al. 1996. J. Med. Chem. 39: 267-276. PMID: 8568816 3. Bos, M., et al. 1997. Clin. Cancer Res. 3: 2099-2106. PMID: 9815602
Soluble in DMSO (10 mM) with gentle warming, water ( <1 mg/mL at 25° C), and ethanol ( <1 mg/mL at 25° C).
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