PD 151746 A selective non-peptidic calpain inhibitor

PD 151746 (CAS 179461-52-0)

PD 151746 is rated 5.0 out of 5 by 1.
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Synonym: 3-(5-Fluoro-3-indolyl)-2-mercapto-(Z)-2-propenoic Acid
Application: A selective non-peptidic calpain inhibitor
CAS Number: 179461-52-0
Purity: ≥95%
Molecular Weight: 237.3
Molecular Formula: C11H8FNO2
* Refer to Certificate of Analysis for lot specific data (including water content).
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PD 151746 is a cell-permeable, non-peptidic, and highly selective calpain inhibitor directed towards the Ca2+ binding sites of calpain. PD 151746 exhibits greater selectivity over calpain-1 than calpain-2. PD 151746 has also been shown to prevent cycloheximide-induced apoptosis.


References

1. Wang, K K., et al., 1996. An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proceedings of the National Academy of Sciences of the United States of America. 93(13): 6687-92. PMID: 8692879
2. Squier, M K., et al., 1999. Calpain and calpastatin regulate neutrophil apoptosis. Journal of cellular physiology. 178(3): 311-9. PMID: 9989777

Physical State :
Solid
Solubility :
Soluble in DMSO (200 mg/ml), and methanol (5 mg/ml).
Storage :
Store at -20° C
Melting Point :
157.54° C (Predicted)
Boiling Point :
~481.4° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.76 (Predicted)
Ki Data :
calpain-1: Ki= 260 nM; calpain-2: Ki= 5.33 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5353866
MDL Number :
MFCD03453564
SMILES :
C1=CC2=C(C=C1F)C(=CN2)/C=C(/C(=O)O)\S

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PD 151746  Product Citations

See how others have used PD 151746. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 24048903  Oliveira, CC. et al. 2013. J. Immunol. 191: 4020-8.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from P rn P rn-Ares MI; et al. (PubMed ID: 12775216) determined that PD 151746 decreased Oxidized low-density lipoprotein induced cytotoxicity in HMEC-1 cells. -SCBT Publication Review
Date published: 2015-05-04
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