PD 151746 is a cell-permeable, non-peptidic, and highly selective calpain inhibitor directed towards the Ca2+ binding sites of calpain. PD 151746 exhibits greater selectivity over calpain-1 than calpain-2. PD 151746 has also been shown to prevent cycloheximide-induced apoptosis.
1. Wang, K K., et al., 1996. An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proceedings of the National Academy of Sciences of the United States of America. 93(13): 6687-92. PMID: 8692879 2. Squier, M K., et al., 1999. Calpain and calpastatin regulate neutrophil apoptosis. Journal of cellular physiology. 178(3): 311-9. PMID: 9989777
Soluble in DMSO (200 mg/ml), and methanol (5 mg/ml).
Store at -20° C
157.54° C (Predicted)
~481.4° C at 760 mmHg (Predicted)
~1.5 g/cm3 (Predicted)
n20D 1.76 (Predicted)
calpain-1: Ki= 260 nM; calpain-2: Ki= 5.33 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Download SDS (MSDS)
Certificate of Analysis
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See how others have used PD 151746. Click on the entry to view the PubMed entry
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Rated 5 out of
P rnP rn-Ares MI; et al. (PubMed ID: 12775216) determined that PD 151746 decreased Oxidized low-density lipoprotein induced cytotoxicity in HMEC-1 cells. -SCBT Publication Review
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