Patulin

Patulin (CAS 149-29-1)

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Synonym: 4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one; Clavacin; Clairformin
Application: An inhibitor of protein prenylation
CAS Number: 149-29-1
Molecular Weight: 154.12
Molecular Formula: C7H6O4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Patulin, a mycotoxin, has been reported to contain antibiotic characteristics. This compound displays the ability to specifically inhibit Na+-K+ ATPase. In murine studies, Patulin was found to inhibit protein prenylation in cells. Mechanistic studies suggest that Patulin reduces incorporation of mevalonate into proteins and prevents protein transferase action, which is required for protein prenylation. Additional experiments show that this mycotoxin also inhibits cell-free microtubule polymerization by covalently reacting with thiol groups of microtubule proteins.


References

1. Riley, R.T., et al. 1990. Toxicol. Appl. Pharmacol. 102: 128-141. PMID: 2153317
2. Miura, S., et al. 1993. FEBS Lett. 318: 88-90. PMID: 8436232
3. Pfeiffer, E., et al. 1998. Carcinogenesis. 19: 1313-1318. PMID: 9683194

Physical State :
Solid
Solubility :
Soluble in water, 100% ethanol (25 mg/mL), ethyl acetate (50 mg/mL), amyl acetate, DMSO (10 mg/mL), acetone, ethyl ether (sparingly), benzene (sparingly), and dichloromethane (10 mg/mL).
Storage :
Store at -20° C
Melting Point :
109-111° C
Boiling Point :
~513.7° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.60 (Predicted)
IC50 :
Hepatitis C virus NS3 protease/helicase: IC50 = 3800 nM (Hepatitis C virus)
pK Values :
pKa: 11.69 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
LV2625000
Transport :
UN 3462, Class 6.1, Packing group II
PubChem CID :
4696
Merck Index :
14: 7053
MDL Number :
MFCD00005858
EC Number :
205-735-2
Beilstein Registry :
149675
SMILES :
C1C=C2C(=CC(=O)O2)C(O1)O

Download SDS (MSDS)

Certificate of Analysis

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Thank you to answer my question but I mean SDS of the monoclonal Antibody Patulin from rabbit?Thanks

Asked by: Al Rubaye
Thank you for your question. We do not offer an antibody against Patulin. Please contact our European Technical Service team, we would be happy to discuss this further with you. You can reach us by phone at Toll Free: +49 6221 4503 0, by email at: europe@scbt.com or by live chat directly on our website, www.scbt.com
Answered by: Tech Service
Date published: 2017-11-28

Hello, my question is how can I get the Safety Data Sheet (SDS) for antibody putulin?Thanks

Asked by: Al Rubaye
Thanks you very much for your inquiry. Unfortunately, we don't offer any antibody against that protein. If you have any further question, please do not hesitate to contact us via email: uk@scbt.com
Answered by: Technical Support Europe
Date published: 2017-11-28
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