PARP Inhibitor XII is a potent quinoxaline-based PARP inhibitor with selectivity towards PARP-2 over PARP-1. PARP plays an active role in DNA repair and triggers apoptosis in severely damaged cells. Inhibition of PARP can reduce the rate of apoptosis in models of reperfusion injury after ischemia.
Ishida, J., et al. 2006. Bioorg. Med. Chem. 14, 1378. Iwashita, A., et al. 2005. FEBS Lett. 579, 1389.
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