PARP Inhibitor XII A potent quinoxaline-based PARP inhibitor

PARP Inhibitor XII

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Application: A potent quinoxaline-based PARP inhibitor
Purity: ≥95%
Molecular Weight: 283.72
Molecular Formula: C15H10ClN3O
* Refer to Certificate of Analysis for lot specific data (including water content).
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PARP Inhibitor XII is a potent quinoxaline-based PARP inhibitor with selectivity towards PARP-2 over PARP-1. PARP plays an active role in DNA repair and triggers apoptosis in severely damaged cells. Inhibition of PARP can reduce the rate of apoptosis in models of reperfusion injury after ischemia.


References

Ishida, J., et al. 2006. Bioorg. Med. Chem. 14, 1378. Iwashita, A., et al. 2005. FEBS Lett. 579, 1389.

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml).
Storage :
Store at 4° C
IC50 :
PARP-2: IC50 = 7 nM; PARP-1: IC50 = 33 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
C1(=CC=CC2=C1N=C(C=N2)C3=CC=C(C=C3)C)C(N([H])[H])=O

Download SDS (MSDS)

Certificate of Analysis

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