PAPA NONOate An NO donor which suppresses the caspase apoptotic cascade

PAPA NONOate (CAS 146672-58-4)

PAPA NONOate | CAS 146672-58-4 is rated 5.0 out of 5 by 1.
  • y_2018, m_12, d_18, h_2
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.9
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_202272, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 74ms
  • REVIEWS, PRODUCT
Synonym: PAPA/NO; NOC-15; 1-(3-aminopropyl)-2-hydroxy-3-oxo-1-propyltriazane
Application: An NO donor which suppresses the caspase apoptotic cascade
CAS Number: 146672-58-4
Purity: >97%
Molecular Weight: 176.22
Molecular Formula: C6H16N4O2
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

PAPA NONOate is a diazeniumdiolate small molecule NO donor with a reported NO release half-life of 77 min (22-25°C). NO release from PAPA NONOate has demonstrated regulation of caspase-3 activity and suppression of the caspase apoptotic cascade via inhibition of S-nitrosylation of the Cys-163 residue on caspase-3. In NO-vacant NT2N cells, NO release from PAPA NONOate produced cell death through apoptotic signaling, as contrasted with the necrotic injury produced by peroxynitrite exposure. NO release from PAPA NONOate is shown to increase cGMP in a model of ischemic lung injury, suggesting that the protective effects of NO against ischemic injury are cGMP-mediated. PAPA NONOate also demonstrated inhibition of protein synthesis in A375 melanoma cells through release of NO, inhibiting thymidine incorporation by 50% (44 μM) and producing a cytostatic effect.


References

1. Riobóo, R., et al., 1976. [Fibrinolysis in the oral cavity]. Revue de stomatologie et de chirurgie maxillo-faciale. 77(2): 287-8. PMID: 1066732
2. Morley, D., et al., 1993. Nitric oxide/nucleophile complexes: a unique class of nitric oxide-based vasodilators. Journal of cardiovascular pharmacology. 22 Suppl 7(): S3-9. PMID: 7504766
3. Maragos, C M., et al., 1993. Nitric oxide/nucleophile complexes inhibit the in vitro proliferation of A375 melanoma cells via nitric oxide release. Cancer research. 53(3): 564-8. PMID: 8425188
4. Keefer, L K., et al., 1996. "NONOates" (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms. Methods in enzymology. 268(): 281-93. PMID: 8782594
5. Gow, A J., et al., 2000. Two distinct mechanisms of nitric oxide-mediated neuronal cell death show thiol dependency. American journal of physiology. Cell physiology. 278(6): C1099-107. PMID: 10837337
6. Pearse, D B., et al., 2000. Effect of time and vascular pressure on permeability and cyclic nucleotides in ischemic lungs. American journal of physiology. Heart and circulatory physiology. 279(5): H2077-84. PMID: 11045940

Physical State :
Solid
Solubility :
Soluble in water (>100 mg/ml at 25° C), and methanol.
Storage :
Store at -20° C
Boiling Point :
277.15° C at 760 mmHg (Predicted)
Density :
1.21 g/cm3 (Predicted)
Refractive Index :
n20D 1.52 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
366046
MDL Number :
MFCD00801020
SMILES :
CCCN(CCCN)N(N=O)O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

PAPA NONOate  Product Citations

See how others have used PAPA NONOate. Click on the entry to view the PubMed entry .

Citations 1 to 9 of 9 total

PMID: # 25749567  Bradley, SA. et al. 2015. J. Neurosci. Methods. 245: 116-24.

PMID: # 17525258  Whitley, GS. et al. 2007. Am. J. Pathol. 170: 1903-1909.

PMID: # 16914531  Zuckerbraun, BS. et al. 2007. Am. J. Physiol., Cell Physiol. 292: C824-C831.

PMID: # 16914531  Zuckerbraun, BS. et al. 2007. Am. J. Physiol., Cell Physiol. 292: C824-C831.

PMID: # 12714605  Kirsch, M. et al. 2003. J. Biol. Chem. 278: 24481-24490.

PMID: # 9864257  Garbe, TR. et al. 1999. Infect. Immun. 67: 460-465.

PMID: # 10362756  Ito, O. et al. 1999. Am. J. Physiol. 276: R1749-R1757.

PMID: # 9730877  Abderrahmane, A. et al. 1998. Am. J. Respir. Cell Mol. Biol. 19: 485-497.

PMID: # 9458808  Gow, AJ. et al. 1998. Am. J. Physiol. 274: L112-L118.

Citations 1 to 9 of 9 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 69ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Whitley et al Whitley et al. (PubMed ID 17525258) used PAPA-NONOate as a nitric oxide donor to determine sensitivities of NO-induced apoptotic signals in pregnancies at risk for preeclampsisa. -SCBT Publication Review
Date published: 2015-04-16
  • y_2018, m_12, d_18, h_2
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.9
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_202272, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 77ms
  • REVIEWS, PRODUCT
--%>

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2018 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.