PAPA NONOate is a diazeniumdiolate small molecule NO donor with a reported NO release half-life of 77 min (22-25°C). NO release from PAPA NONOate has demonstrated regulation of caspase-3 activity and suppression of the caspase apoptotic cascade via inhibition of S-nitrosylation of the Cys-163 residue on caspase-3. In NO-vacant NT2N cells, NO release from PAPA NONOate produced cell death through apoptotic signaling, as contrasted with the necrotic injury produced by peroxynitrite exposure. NO release from PAPA NONOate is shown to increase cGMP in a model of ischemic lung injury, suggesting that the protective effects of NO against ischemic injury are cGMP-mediated. PAPA NONOate also demonstrated inhibition of protein synthesis in A375 melanoma cells through release of NO, inhibiting thymidine incorporation by 50% (44 μM) and producing a cytostatic effect.
1. Riobóo, R., et al., 1976. [Fibrinolysis in the oral cavity]. Revue de stomatologie et de chirurgie maxillo-faciale. 77(2): 287-8. PMID: 1066732 2. Morley, D., et al., 1993. Nitric oxide/nucleophile complexes: a unique class of nitric oxide-based vasodilators. Journal of cardiovascular pharmacology. 22 Suppl 7(): S3-9. PMID: 7504766 3. Maragos, C M., et al., 1993. Nitric oxide/nucleophile complexes inhibit the in vitro proliferation of A375 melanoma cells via nitric oxide release. Cancer research. 53(3): 564-8. PMID: 8425188 4. Keefer, L K., et al., 1996. "NONOates" (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms. Methods in enzymology. 268(): 281-93. PMID: 8782594 5. Gow, A J., et al., 2000. Two distinct mechanisms of nitric oxide-mediated neuronal cell death show thiol dependency. American journal of physiology. Cell physiology. 278(6): C1099-107. PMID: 10837337 6. Pearse, D B., et al., 2000. Effect of time and vascular pressure on permeability and cyclic nucleotides in ischemic lungs. American journal of physiology. Heart and circulatory physiology. 279(5): H2077-84. PMID: 11045940
Soluble in water (>100 mg/ml at 25° C), and methanol.
Store at -20° C
277.15° C at 760 mmHg (Predicted)
1.21 g/cm3 (Predicted)
n20D 1.52 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Whitley et alWhitley et al. (PubMed ID 17525258) used PAPA-NONOate as a nitric oxide donor to determine sensitivities of NO-induced apoptotic signals in pregnancies at risk for preeclampsisa. -SCBT Publication Review
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