Panobinostat Panobinostat (LBH589) is a HDAC (histone deactylase) inhibitor of research interest for multiple diseases such as multiple myeloma.

Panobinostat  (CAS 404950-80-7)

Panobinostat is rated 5.0 out of 5 by 1.
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Synonym: LBH 589; (E)-N-Hydroxy-3-(4-(((2-(2-methyl-1H-indol-3-yl)ethyl)amino)methyl)phenyl)acrylamide
Application: An HDAC inhibitor reported to inhibit human multiple myeloma cell lines
CAS Number: 404950-80-7
Purity: ≥98%
Molecular Weight: 349.43
Molecular Formula: C21H23N3O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Panobinostat sc-208148 10 mg $186.00

Panobinostat (LBH589) is a HDAC (histone deactylase) inhibitor of research interest for multiple diseases such as multiple myeloma. The deacetylation of histones is associated with transcriptional silencing. Panobinostat was reported to inhibit several human myeloma cell lines with IC50 ≥ 20nM. Panobinostat was also reported to induce expression of DNA damage response genes and induce apoptosis in Ph- acute lymphoblastic leukemia cells.


References

1. Catley, L., et al. 2006. Blood. 108: 3441-3449. PMID: 16728695
2. Fiskus, W., et al. 2006. Mol. Cancer Ther. 5: 3096-3104. PMID: 17172412
3. Scuto, A., et al. 2008. Blood. 111: 5093-5100. PMID: 18349321
4. Sasaki, D., et al. 2011. Haematologica. PMID: 21228036. PMID: 21228036

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (70 mg/ml), methanol, water (<1.2 mg/ml), DMF (~50 mg/ml), and ethanol (~3.3 mg/ml).
Storage :
Store at -20° C
Melting Point :
>115° C (dec.)
Boiling Point :
608.15° C (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
Histone deacetylase: IC50 = 1.8 nM (Plasmodium falciparum); HDAC1: IC50 = 6.8 nM (human); COLO 205: IC50 = 18 nM (human); PC-3: IC50 = 24 nM (human); A2780: IC50 = 35 nM (human)
Ki Data :
HDAC4: Ki= 0.6 nM (human); HDAC2: Ki= 0.65 nM (human); HDAC6: Ki= 0.7 nM (human); HDAC5: Ki= 0.7 nM (human); HDAC1: Ki= 1 nM (human)
pK Values :
pKa: 8.71 (Predicted), pKb: 9.3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
UC6378000
PubChem CID :
6918837
MDL Number :
MFCD09833242
SMILES :
CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from An increase in Ac An increase in Ac-Histone H4 protein expression was observed by WB in A549 cells post treatment with Panobinostat. -SCBT QC
Date published: 2015-04-16
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