Oxytetracycline is an anti-inflammatory, antibiotic, and anti-proliferative agent shown to inhibit mitochondrial protein synthesis. Mechanistic studies show that this compound reduces cytochrome c activity which eventually causes cell growth arrest. Additionally, Oxytetracycline has demonstrated the ability to reduce murine bronchial inflammation. The anti-inflammatory characteristics of this agent are due to its ability to cause a decrease in IL-4, IL-5, IL-13, immune cells, and the ovalbumin-specific IgE. Data suggests that Oxytetracycline is also an inhibitor of NF-κB activation via phosphorylation and degradation of IκB-α.
1. van den Bogert, C., et al. 1981. Cancer Res. 41: 1943-1947. PMID: 7214362 2. van den Bogert, C., et al. 1983. Cancer Res. 43: 2247-2251. PMID: 6831447 3. Ci, X., et al. 2010. J. Clin. Immunol. [Epub ahead of print]. PMID: 21136283
Soluble in DMSO (92 mg/ml at 25° C), water (<1 mg/ml at 25° C), and ethanol (10 mg/ml at 25° C).
Store at room temperature
~727.8° C at 760 mmHg (Predicted)
~1.7 g/cm3 (Predicted)
n20D 1.76 (Predicted)
α20/D -196.6° in 0.1 N HCl; α20/D -2.1° in 0.1 N NaOH; α25/D +26.5° in methanol
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
SeoSeo, HB. et al. (PubMed 26334055) presented a a novel reflectance-based colorimetric aptasensor using gold nanoparticles for the detection of Oxytetracycline for the first time. They were able to detect Oxytetracycline at concentrations as low as 1nM in both buffer solution and tap water. -SCBT Publication Review
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