Oxolinic Acid A quinoline antibacterial compound and inhibitor of Topo II

Oxolinic Acid (CAS 14698-29-4)

Oxolinic Acid | CAS 14698-29-4 is rated 5.0 out of 5 by 1.
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Synonym: 5,8-Dihydro-5-ethyl-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid
Application: A quinoline antibacterial compound and inhibitor of Topo II
CAS Number: 14698-29-4
Purity: ≥98%
Molecular Weight: 261.23
Molecular Formula: C13H11NO5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Oxolinic Acid is a quinolone antibacterial agent and an inhibitor of Topo II.


References

1. DiCarlo, F.J., et al. 1968. Arch. Biochem. Biophys. 127: 503-511. PMID: 5698001
2. Crew, M.C., et al. 1971. Xenobiotica. 1: 193-201. PMID: 5173021
3. Wright, H.T., et al. 1981. Science. 213: 455-456. PMID: 7017932

Physical State :
Solid
Solubility :
Soluble in aqueous base, 0.5 M NaOH (50 mg/ml), with heat as needed, yielding a clear, colorless solution, and formic acid. Partly miscible in water. Insoluble in DMF, and DMSO.
Storage :
Store at 4° C
Melting Point :
314-316° C (dec.)
Boiling Point :
473.2±45.0° C at 760 mmHg (Predicted)
Density :
1.5±0.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
IC50 :
PhoP regulon : IC50 = 42.97 µM (Salmonella Typhimurium)
pK Values :
pKa: 5.94
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
JI5075000
PubChem CID :
4628
Merck Index :
14: 6945
MDL Number :
MFCD00056775
EC Number :
238-750-8
Beilstein Registry :
620635
SMILES :
CCN1C=C(C(O)=O)C(=O)C2=CC3=C(OCO3)C=C12

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Wright Wright, HT. et al. (PubMed 7017932) reported that Oxolinic Acid inhibits yeast glycyl- and leucyl-transfer RNA synthetases. -SCBT Publication Review
Date published: 2015-06-02
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