Oxiconazole Nitrate An antifungal agent

Oxiconazole Nitrate (CAS 64211-46-7)

Oxiconazole Nitrate | CAS 64211-46-7 is rated 5.0 out of 5 by 1.
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Synonym: Myfungar; Oceral; Oxistat; Okiconale
Application: An antifungal agent
CAS Number: 64211-46-7
Molecular Weight: 492.14
Molecular Formula: C18H13Cl4N3O•HNO3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Oxiconazole Nitrate is an antifungal agent. Clinically, it is typically administered in a cream or lotion to treat skin infections such as athlete's foot, jock itch and ringworm. Oxiconazole nitrate is an imidazole derivative and functions by inhibiting ergosterol biosynthesis, which is critical for cellular membrane integrity in fungi. The azole component of oxiconazole nitrate inhibits the enzyme that performs the demethylation steps in the biosynthetic pathway that synthesizes ergosterol from lanosterol.


References

Polak A. Arzneimittelforschung. 32:17-24 (1982).

Physical State :
Solid
Solubility :
Soluble in chloroform, and methanol.
Storage :
Store at room temperature
Melting Point :
137-138° C
Refractive Index :
n20D ~1.64 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9556529
MDL Number :
MFCD01727545
EC Number :
264-730-3
SMILES :
C1=CC(=C(C=C1Cl)Cl)CON=C(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl.[N+](=O)(O)[O-]

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Certificate of Analysis

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Rated 5 out of 5 by from Polak (PubMed ID 7037014) found that Oxiconazole Polak (PubMed ID 7037014) found that Oxiconazole Nitrate showed antifungal activity against Aspergillus fumigatus, Cryptococcus neoformans, Candida albicans and Trichophyton mentagrophytes by inhibiting DNA and RNA synthesis. -SCBT Publication Review
Date published: 2015-07-12
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