Oxaliplatin

Oxaliplatin (CAS 61825-94-3)

Oxaliplatin | CAS 61825-94-3 is rated 5.0 out of 5 by 1.
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Application: A potent anti-neoplastic agent that binds to DNA and shows efficacy in Cisplatin resistant cell lines
CAS Number: 61825-94-3
Purity: 99%
Molecular Weight: 397.3
Molecular Formula: C8H14N2O4Pt
* Refer to Certificate of Analysis for lot specific data (including water content).
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Oxaliplatin is a second generation potent platinum-based anti-neoplastic agent that is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The development of Oxaliplatin was inspired from the efficacy of its progenitor, Cisplatin (sc-200896), the first of this class of anti-neoplastic agents. Oxaliplatin displays higher cytotoxicity and lower nephrotoxicity than Cisplatin (sc-200896) or Carboplatin (sc-202093), and shows antitumor activity in cell lines with acquired Cisplatin (sc-200896) resistance. The enhanced activity of Oxaliplatin compared to other members of this class is attributed to the bulky diaminocyclohexane ligand in the major groove that might limit the flexibility of the Oxaliplatin-DNA adduct, and interfere with DNA repair enzymes differently.


References

1. Culy, C.R., et al. 2000. Drugs. 60: 895-924. PMID: 11085200
2. Mani, S., et al. 2002. Cancer Invest. 20: 246-263. PMID: 11901545
3. MacDonald, J.S., 2002. Cancer Invest. 20: 287-289. PMID: 11901548
4. Raymond, E., et al. 2002. Mol. Cancer Ther. 1: 227-235. PMID: 12467217

Physical State :
Solid
Solubility :
Soluble in water (7.9 mg/ml), methanol (slightly), and DMSO (50 mM). Insoluble in ethanol.
Storage :
Store at -20° C
Melting Point :
>245° C (dec.)
Optical Activity :
α20/D +75.2°, c = 0.3 in water
IC50 :
Ovarian carcinoma cell line A2780: IC50 = 0.17 µM; Colon carcinoma cell line HT-29: IC50 = 0.97 µM; melanoma cell lines HT-144: IC50 = 7.85 µM; Rladder carcinoma cell lines RT4: IC50 = 11 µM; Rladder carcinoma cell lines TCCSUP: IC50 = 15 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
TP2275850
PubChem CID :
24197464
Merck Index :
14: 6912
MDL Number :
MFCD00866327
SMILES :
C1CC[C@H]([C@@H](C1)N)N.C(=O)(C(=O)[O-])[O-].[Pt+4]

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Oxaliplatin  Product Citations

See how others have used Oxaliplatin. Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 28265008  Liu, CW. et al. 2017. Mol. Cancer Ther. 16: 1421-1434.

PMID: # 26715744  De Gassart, A. et al. 2016. Proc. Natl. Acad. Sci. U.S.A. 113: E117-26.

PMID: # 25884497  Gabriel, M. et al. 2015. BMC Cancer. 15: 227.

PMID: # 24667756  Negreira, N. et al. 2014. The Science of the total environment. 482-483: 389-98.

PMID: # 24148406  2013. Talanta. 116: 290-9.

PMID: # 19418581  Schimanski CC et al. 2009. World J Gastroenterol. 15: 2089-2096.

Citations 1 to 6 of 6 total

What is the price of bulk amount : 2.5 gram?

Asked by: SnehaDas
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Rated 5 out of 5 by from A decrease in survivin protein expression A decrease in survivin protein expression in HCT 116 cells was observed by WB post treatment with oxaliplatin. -SCBT QC
Date published: 2015-01-17
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