Oxaliplatin is a second generation potent platinum-based anti-neoplastic agent that is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The development of Oxaliplatin was inspired from the efficacy of its progenitor, Cisplatin (sc-200896), the first of this class of anti-neoplastic agents. Oxaliplatin displays higher cytotoxicity and lower nephrotoxicity than Cisplatin (sc-200896) or Carboplatin (sc-202093), and shows antitumor activity in cell lines with acquired Cisplatin (sc-200896) resistance. The enhanced activity of Oxaliplatin compared to other members of this class is attributed to the bulky diaminocyclohexane ligand in the major groove that might limit the flexibility of the Oxaliplatin-DNA adduct, and interfere with DNA repair enzymes differently.
1. Culy, C.R., et al. 2000. Drugs. 60: 895-924. PMID: 11085200 2. Mani, S., et al. 2002. Cancer Invest. 20: 246-263. PMID: 11901545 3. MacDonald, J.S., 2002. Cancer Invest. 20: 287-289. PMID: 11901548 4. Raymond, E., et al. 2002. Mol. Cancer Ther. 1: 227-235. PMID: 12467217
Soluble in water (7.9 mg/ml), methanol (slightly), and DMSO (50 mM). Insoluble in ethanol.
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