Oxaliplatin is a second generation potent platinum-based anti-neoplastic agent that is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The development of Oxaliplatin was inspired from the efficacy of its progenitor, Cisplatin (sc-200896), the first of this class of anti-neoplastic agents. Oxaliplatin displays higher cytotoxicity and lower nephrotoxicity than Cisplatin (sc-200896) or Carboplatin (sc-202093), and shows antitumor activity in cell lines with acquired Cisplatin (sc-200896) resistance. The enhanced activity of Oxaliplatin compared to other members of this class is attributed to the bulky diaminocyclohexane ligand in the major groove that might limit the flexibility of the Oxaliplatin-DNA adduct, and interfere with DNA repair enzymes differently.
1. Culy, C.R., et al. 2000. Drugs. 60: 895-924. PMID: 11085200
2. Mani, S., et al. 2002. Cancer Invest. 20: 246-263. PMID: 11901545
3. MacDonald, J.S., 2002. Cancer Invest. 20: 287-289. PMID: 11901548
4. Raymond, E., et al. 2002. Mol. Cancer Ther. 1: 227-235. PMID: 12467217
See how others have used Oxaliplatin. Click on the entry to view the PubMed entry .
PMID: # 28265008 Liu, CW. et al. 2017. Mol. Cancer Ther. 16: 1421-1434.
PMID: # 26715744 De Gassart, A. et al. 2016. Proc. Natl. Acad. Sci. U.S.A. 113: E117-26.
PMID: # 25884497 Gabriel, M. et al. 2015. BMC Cancer. 15: 227.
PMID: # 25175346 Hagos, Y. et al. 2014. J Pharm Sci. 103: 3326-34.
PMID: # 24667756 Negreira, N. et al. 2014. The Science of the total environment. 482-483: 389-98.
PMID: # 24148406 2013. Talanta. 116: 290-9.
PMID: # 19418581 Schimanski CC et al. 2009. World J Gastroenterol. 15: 2089-2096.
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