Osmium tetroxide is widely used to oxidise alkenes to the vicinal diols, adding two hydroxyl groups at the same side (syn addition). It is also used in catalytic amounts in the Sharpless oxyamination to give vicinal amino-alcohols. Osmium tetroxide is also a widely used staining agent used in transmission electron microscopy (TEM) to provide contrast to the image.
See how others have used Osmium tetroxide. Click on the entry to view the PubMed entry .
PMID: # 23169061
Pellegrini, C. et al. 2013. Melanocytes--a novel tool to study mitochondrial dysfunction in Duchenne muscular dystrophy. J. Cell. Physiol.. 228: 1323-1331.
PMID: # 22711985
Blättler, SM. et al. 2012. Defective mitochondrial morphology and bioenergetic function in mice lacking the transcription factor Yin Yang 1 in skeletal muscle. Mol. Cell. Biol.. 32: 3333-3346.
PMID: # 22200571
Sekimoto, J. et al. 2012. Dissociation of the insulin receptor from caveolae during TNFα-induced insulin resistance and its recovery by D-PDMP. FEBS Lett.. 586: 191-195.
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