OR-486 A COMT inhibitor

OR-486 (CAS 7659-29-2)

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Synonym: 3,5-Dinitrocatechol
Application: A COMT inhibitor
CAS Number: 7659-29-2
Purity: ≥98%
Molecular Weight: 200.11
Molecular Formula: C6H4N2O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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OR-486 is a potent and selective catechol-O-methyl transferase inhibitor (COMT). COMT functions to methylate catecholamine neurotransmitters. OR-486 has also been shown to be a chelating reagent useful in vanadium assays.


References

Borgulya et al (1989) Catechol-O-methyltransferase-inhibiting pyrocatechol derivatives: synthesis and structure-activity studies. Helv.Chim.Acta 72 952. Mannisto and Kaakola (1990) Rationale for selective COMT inhibitors as adjuncts in the drug treatment of Parkinsons disease. Pharmacol.Toxicol. 66 317.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble to 100 mM in Ethanol and to 100 mM in DMSO
Storage :
Store at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
3870203
SMILES :
C1=C(C=C(C(=C1[N+](=O)[O-])O)O)[N+](=O)[O-]

Download SDS (MSDS)

Certificate of Analysis

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