OR-486 is a potent and selective catechol-O-methyl transferase inhibitor (COMT). COMT functions to methylate catecholamine neurotransmitters. OR-486 has also been shown to be a chelating reagent useful in vanadium assays.
Borgulya et al (1989) Catechol-O-methyltransferase-inhibiting pyrocatechol derivatives: synthesis and structure-activity studies. Helv.Chim.Acta 72 952. Mannisto and Kaakola (1990) Rationale for selective COMT inhibitors as adjuncts in the drug treatment of Parkinsons disease. Pharmacol.Toxicol. 66 317.
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