Optineurin Antibody (C-2) is a mouse monoclonal IgG2b (kappa light chain) provided at 200 µg/ml
raised against a peptide mapping near the N-terminus of Optineurin of human origin
recommended for detection of Optineurin of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including bovine
available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
blocking peptide, sc-166576 P
See m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP), our highly recommended recombinant alternative to conventional secondary anti-mouse IgG reagents.
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of Optineurin (C-2): sc-166576.
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Optineurin, also designated FIP2, E3-14.7K-interacting protein, HYPL, transcription factor IIIA-interacting protein (TFIIIA-INTP), Huntingtin interacting protein L and NEMO-related protein, influences cell morphogenesis, membrane trafficking, vesicle trafficking and transcription activation through its interactions with the Rab8, Huntingtin and transcription factor IIIA proteins. Optineurin interacts with adenovirus E3-14.7K protein and may utilize TNFa or FAS-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin mutations may impart normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin is a 617 amino acid protein that contains leucine zippers and leucine-rich regions, and contains a potential Cys2-His-Cys zinc finger at residues 553-582. It localizes to the Golgi apparatus. RT-PCR studies indicate expression in human trabecular meshwork, nonpigmented ciliary epithelium, retina, brain, adrenal cortex, liver, fetus, lymphocyte and fibroblast. Northern blot studies indicate a 2.0 kb transcript in human trabecular meshwork and nonpigmented ciliary epithelium and a minor 3.6 kb transcript.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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