Ophiobolin A An inhibitor of calmodulin action in calcium regulation

Ophiobolin A (CAS 4611-05-6)

Ophiobolin A | CAS 4611-05-6 is rated 5.0 out of 5 by 1.
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Synonym: Cochliobolin A
Application: An inhibitor of calmodulin action in calcium regulation
CAS Number: 4611-05-6
Purity: >95%
Molecular Weight: 400.6
Molecular Formula: C25H36O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ophiobolin A is the dominant member of a class of phytotoxic metabolites produced by plant pathogenic fungi. Ophiobolin A acts as an inhibitor of calmodulin action in calcium regulation. In-house testing at Microbial Screening Technologies has shown that Ophiobolin A is an inhibitor of PDE. Ophiobolin A is an inhibitor of CaM.


References

1. Quetglas S., et al. 2002. EMBO J. 21: 3970.-3979. PMID: 12145198
2. Au, T.K., et al. 2000. Life Sci. 67: 733-742. PMID: 10968403

Physical State :
Solid
Derived From :
Bipolaris leersia
Solubility :
Soluble in DMSO, DMF, 100% ethanol, and methanol.
Storage :
Store at -20° C
Melting Point :
206.52° C (Predicted)
Boiling Point :
539.45° C at 760 mmHg (Predicted)
Density :
1.14 g/cm3 (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
IC50 :
P388: IC50 = 0.03 ug.mL-1 (mouse); A549: IC50 = 0.05 ug.mL-1 (human); HT-29: IC50 = 0.05 ug.mL-1 (human); Plasmodium falciparum: IC50 = 0.53 ug.mL-1
pK Values :
pKa: 13.85 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
RL1576000
PubChem CID :
5281387
MDL Number :
MFCD00058400
SMILES :
C[C@H]1C[C@@H](O[C@@]12CC[C@]3([C@H]2C/C=C(\[C@@H]4[C@H](C3)[C@](CC4=O)(C)O)/C=O)C)C=C(C)C

Download SDS (MSDS)

Certificate of Analysis

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Ophiobolin A  Product Citations

See how others have used Ophiobolin A. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 21900509  Sarria, I. et al. 2011. Journal of neurophysiology. 106: 3056-66.

PMID: # 12200418  Lin, K. et al. 2002. J. Biol. Chem. 277: 40789-40798.

Kim, HJ et al. 1999. Plant Pathology. 15: 14-20.

Citations 1 to 3 of 3 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Ophiobolin A, sc-202266, is a white solid.
Answered by: Chemical Support 4
Date published: 2017-04-06
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Rated 5 out of 5 by from Lin et al Lin et al. (PubMed ID 12200418) used Ophiobolin A, a calmodulin (CaM) inhibitor, to study CaM and calcineurin involvement in SRF activation mediated by M1. -SCBT Publication Review
Date published: 2015-02-22
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