Omi/HtrA2 Protease Inhibitor, Ucf-101 A cell-permeable furfurylidine-thiobarbituric acid

Omi/HtrA2 Protease Inhibitor, Ucf-101 (CAS 313649-08-0)

Omi/HtrA2 Protease Inhibitor, Ucf-101 | CAS 313649-08-0 is rated 5.0 out of 5 by 1.
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Application: A cell-permeable furfurylidine-thiobarbituric acid
CAS Number: 313649-08-0
Purity: ≥97%
Molecular Weight: 495.5
Molecular Formula: C27H17N3O5S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Omi/HtrA2 Protease Inhibitor, Ucf-101 is a cell-permeable furfurylidine-thiobarbituric acid compound that acts as a potent, specific, competitive, and reversible inhibitor of the pro-apoptotic, heat-inducible, mitochondrial serine protease Omi/HtrA2 (IC50 = 9.5 μM for His-Omi134-458). Shows very little activity against various other serine proteases tested (IC50 ≥ 200 μM). Reported to block Omi/HtrA2 induced cell death in caspase-9 (-/-) null fibroblasts.


References

1. Cilenti, L. et al. 2003. J. Biol. Chem. 278(13): 11489-11494. PMID: 12529364

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/ml).
Storage :
Store at 4° C
Density :
~1.50 g/cm3 (Predicted)
Refractive Index :
n20D ~1.76 (Predicted)
IC50 :
His-Omi134-458: IC50 = 9.5 µM; various other serine proteases: IC50 = ≥ 200 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
MDL Number :
MFCD01000361
SMILES :
C1(=C(C=CC=C1)N(O)O)C2=CC=C(O2)C=C3C(N(C(N(C3=O)C4=CC=CC=C4)=S)C5=CC=CC=C5)=O

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Certificate of Analysis

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Omi/HtrA2 Protease Inhibitor, Ucf-101  Product Citations

See how others have used Omi/HtrA2 Protease Inhibitor, Ucf-101. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 25408502  Gmeiner, WH. et al. 2015. Prostate. 75: 360-9.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Hu Hu, Y. et al. (PubMed 23557966) reported that Omi/HtrA2 Protease Inhibitor, Ucf-101 protects against cerebral oxidative injury and cognitive impairment in septic rats. -SCBT Publication Review
Date published: 2015-04-09
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