Omi/HtrA2 Protease Inhibitor, Ucf-101 is a cell-permeable furfurylidine-thiobarbituric acid compound that acts as a potent, specific, competitive, and reversible inhibitor of the pro-apoptotic, heat-inducible, mitochondrial serine protease Omi/HtrA2 (IC50 = 9.5 μM for His-Omi134-458). Shows very little activity against various other serine proteases tested (IC50 ≥ 200 μM). Reported to block Omi/HtrA2 induced cell death in caspase-9 (-/-) null fibroblasts.
1. Cilenti, L. et al. 2003. J. Biol. Chem. 278(13): 11489-11494. PMID: 12529364
Soluble in DMSO (5 mg/ml).
Store at 4° C
~1.50 g/cm3 (Predicted)
n20D ~1.76 (Predicted)
His-Omi134-458: IC50 = 9.5 µM; various other serine proteases: IC50 = ≥ 200 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
HuHu, Y. et al. (PubMed 23557966) reported that Omi/HtrA2 Protease Inhibitor, Ucf-101 protects against cerebral oxidative injury and cognitive impairment in septic rats. -SCBT Publication Review
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