Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. It is effective against several chemically induced tumor models. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. Oltipraz is an activator of Nrf2.
Bueding E, Dolan P, Leroy JP. Res Commun Chem Pathol Pharmacol. 37:293-303 (1982). Wattenberg LW, Bueding E. Carcinogenesis. 7:1379-81 (1986). Kensler T, Styczynski P, Groopman J et al. J Cell Biochem Suppl. 16I:167-72 (1992).
Soluble in methanol, and DMSO ( >20 mg/ml).
Store at 4° C
~408.1° C at 760 mmHg (Predicted)
~1.5 g/cm3 (Predicted)
n20D 1.76 (Predicted)
CYP1A2: Ki= 9 µM (human)
pKb: 0.18 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
EbaEba, S. et al. (PubMed 23590302) reported that the nuclear factor erythroid 2-related factor 2 activator Oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice. -SCBT Publication Review
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