Oltipraz An antischistosomiasis inhibitor of carcinogenesis

Oltipraz (CAS 64224-21-1)

Oltipraz | CAS 64224-21-1 is rated 5.0 out of 5 by 1.
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Synonym: 4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione; RP 35972; NSC 347901; BRN 0978110
Application: An antischistosomiasis inhibitor of carcinogenesis
CAS Number: 64224-21-1
Purity: ≥98%
Molecular Weight: 226.34
Molecular Formula: C8H6N2S3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. It is effective against several chemically induced tumor models. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. Oltipraz is an activator of Nrf2.


References

Bueding E, Dolan P, Leroy JP. Res Commun Chem Pathol Pharmacol. 37:293-303 (1982). Wattenberg LW, Bueding E. Carcinogenesis. 7:1379-81 (1986). Kensler T, Styczynski P, Groopman J et al. J Cell Biochem Suppl. 16I:167-72 (1992).

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in methanol, and DMSO ( >20 mg/ml).
Storage :
Store at 4° C
Melting Point :
165-166° C
Boiling Point :
~408.1° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.76 (Predicted)
Ki Data :
CYP1A2: Ki= 9 µM (human)
pK Values :
pKb: 0.18 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
JP1293000
PubChem CID :
47318
MDL Number :
MFCD00868499
EC Number :
264-736-6
Beilstein Registry :
0978110
SMILES :
CC1=C(SSC1=S)C2=NC=CN=C2

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Eba Eba, S. et al. (PubMed 23590302) reported that the nuclear factor erythroid 2-related factor 2 activator Oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice. -SCBT Publication Review
Date published: 2015-02-13
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