Olomoucine II is a selective inhibitor of Cdk1(CDK1)/cyclin B (IC50 = 20 nM). Olomoucine II is a potent cytotoxin in tumor cells: IC50 = 5.3 μM against MCF7 cells, IC50 = 11.1 μM against K562 cells, IC50 = 3.0 μM against CEM cells, IC50 = 6.3 μM against HOS cells, and IC50 = 6.3 μM against G361 cells.
1. Krystof, V., et al. 2002. Bioorg. Med. Chem. Lett. 12: 3283-3286. PMID: 12392733
2. Krystof, V., et al. 2005. Cell Mol. Life Sci. 62: 1763-1771. PMID: 16003486
Soluble in DMSO, DMF, 100% ethanol, and chloroform (50 mg/ml).
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