Olomoucine II is a selective inhibitor of Cdk1(CDK1)/cyclin B (IC50 = 20 nM). Olomoucine II is a potent cytotoxin in tumor cells: IC50 = 5.3 μM against MCF7 cells, IC50 = 11.1 μM against K562 cells, IC50 = 3.0 μM against CEM cells, IC50 = 6.3 μM against HOS cells, and IC50 = 6.3 μM against G361 cells.
1. Krystof, V., et al. 2002. Bioorg. Med. Chem. Lett. 12: 3283-3286. PMID: 12392733
2. Krystof, V., et al. 2005. Cell Mol. Life Sci. 62: 1763-1771. PMID: 16003486
Soluble in DMSO, DMF, 100% ethanol, and chloroform (50 mg/ml).
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.