Oligomycin B An antibiotic that acts as a nonselective inhibitor of ATP synthase

Oligomycin B (CAS 11050-94-5)

Oligomycin B | CAS 11050-94-5 is rated 5.0 out of 5 by 1.
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Synonym: 28-Oxooligomycin A
Application: An antibiotic that acts as a nonselective inhibitor of ATP synthase
CAS Number: 11050-94-5
Purity: >95%
Molecular Weight: 805.05
Molecular Formula: C45H72O12
* Refer to Certificate of Analysis for lot specific data (including water content).
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Oligomycin B is an antibiotic that acts as a nonselective inhibitor of ATP5 (ATP synthase), produced by Streptomyces sp. Myocardial ischemia studies have revealed that Oligomycin B can reduce the rate of ATP depletion. Oligomycin B has been reported to decrease oscillation frequency in rat sensory neuron studies. Additional studies have demonstrated that Oligomycin B can increase mRNA levels of GLUT1.


References

1. Rozé, C., et al. 1977. Gastroenterol. Clin. Biol. 1: 435-446. PMID: 892317
2. Chen, F. and Cushion, M.T. 1994. J. Clin. Microbiol. 32: 2791-2800. PMID: 7852574
3. Bergemann, C., et al. 2001. Life Sci. 69: 1391-1406. PMID: 11531163
4. Kabanov, A.E., et al. 2003. Antibiot. Khimioter. 48: 16-20. PMID: 15004975
5. Jackson, J.G., et al. 2006. J. Neurophysiol. 96: 1093-1104. PMID: 16760347
6. Grover, G.J., et al. 2008. Cardiovasc Ther. 26: 287-296. PMID: 19035880

Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in 100% ethanol, methanol, DMSO, and DMF. Insoluble in water.
Storage :
Store at -20° C
Melting Point :
160-161° C
Boiling Point :
911.40° C at 760 mmHg (Predicted)
Density :
1.18 g/cm3 (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
RK3330000
PubChem CID :
5281900
Merck Index :
14: 6833
MDL Number :
MFCD00043232
EC Number :
234-275-5
Beilstein Registry :
5705502
SMILES :
CC[C@H]\\1CC[C@@H]2[C@@H]([C@@H]([C@H]([C@@]3(O2)C(=O)C[C@H]([C@H](O3)C[C@H](C)O)C)C)OC(=O)/C=C/[C@H]([C@@H]([C@H](C(=O)[C@H]([C@@H]([C@H](C(=O)[C@@]([C@@H]([C@H](C/C=C/C=C1)C)O)(C)O)C)O)C)C)O)C)C

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Oligomycin B  Product Citations

See how others have used Oligomycin B. Click on the entry to view the PubMed entry .

Citations 1 to 9 of 9 total

PMID: # 16257969  Tomasinsig, L. et al. 2006. J. Biol. Chem. 281: 383-391.

PMID: # 10444435  Jekabsons, MB. et al. 1999. Am. J. Physiol. 277: E380-E389.

PMID: # 2155067  Pesaturo, JA. et al. 1990. Circ. Res. 66: 696-709.

PMID: # 2577130  Burger, PM. et al. 1989. Neuron. 3: 715-720.

PMID: # 2903047  Hell, JW. et al. 1988. EMBO J. 7: 3023-3029.

PMID: # 2902091  Maycox, PR. et al. 1988. J. Biol. Chem. 263: 15423-15428.

PMID: # 6610568  Yeaman, SJ. et al. 1984. FEBS Lett. 172: 38-42.

PMID: # 6489513  Kerbey, AL. et al. 1984. FEBS Lett. 176: 115-119.

PMID: # 5664204  Jasper, DK. et al. 1968. J. Cell Biol. 38: 277-291.

Citations 1 to 9 of 9 total
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Rated 5 out of 5 by from Tomasinsig et al Tomasinsig et al. (PubMed ID 16257969) used Oligomycin B, an antibiotic that acts as a nonselective ATP synthase inhibitor, to study energy depletion in mammalian cells. -SCBT Publication Review
Date published: 2015-04-26
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