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Oligomycin B (CAS 11050-94-5)

Oligomycin B | CAS 11050-94-5 is rated 5.0 out of 5 by 1.

See product citations (9)

Synonym: 28-Oxooligomycin A

Application: An antibiotic that acts as a nonselective inhibitor of ATP synthase

CAS Number: 11050-94-5

Purity: >95%

Molecular Weight: 805.05

Molecular Formula: C₄₅H₇₂O₁₂

* Refer to Certificate of Analysis for lot specific data (including water content).

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Oligomycin B is an antibiotic that acts as a nonselective inhibitor of ATP5 (ATP synthase), produced by Streptomyces sp. Myocardial ischemia studies have revealed that Oligomycin B can reduce the rate of ATP depletion. Oligomycin B has been reported to decrease oscillation frequency in rat sensory neuron studies. Additional studies have demonstrated that Oligomycin B can increase mRNA levels of GLUT1.

References

1. Rozé, C., et al. 1977. Gastroenterol. Clin. Biol. 1: 435-446. PMID: 892317
2. Chen, F. and Cushion, M.T. 1994. J. Clin. Microbiol. 32: 2791-2800. PMID: 7852574
3. Bergemann, C., et al. 2001. Life Sci. 69: 1391-1406. PMID: 11531163
4. Kabanov, A.E., et al. 2003. Antibiot. Khimioter. 48: 16-20. PMID: 15004975
5. Jackson, J.G., et al. 2006. J. Neurophysiol. 96: 1093-1104. PMID: 16760347
6. Grover, G.J., et al. 2008. Cardiovasc Ther. 26: 287-296. PMID: 19035880

Physical State :

Solid

Derived From :

Streptomyces sp.

Solubility :

Soluble in 100% ethanol, methanol, DMSO, and DMF. Insoluble in water.

Storage :

Store at -20° C

Melting Point :

160-161° C

Boiling Point :

911.40° C at 760 mmHg (Predicted)

Density :

1.18 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.55 (Predicted)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

WGK Germany :

RTECS :

RK3330000

PubChem CID :

5281900

Merck Index :

14: 6833

MDL Number :

MFCD00043232

EC Number :

234-275-5

Beilstein Registry :

5705502

SMILES :

CC[C@H]\\1CC[C@@H]2[C@@H]([C@@H]([C@H]([C@@]3(O2)C(=O)C[C@H]([C@H](O3)C[C@H](C)O)C)C)OC(=O)/C=C/[C@H]([C@@H]([C@H](C(=O)[C@H]([C@@H]([C@H](C(=O)[C@@]([C@@H]([C@H](C/C=C/C=C1)C)O)(C)O)C)O)C)C)O)C)C

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Oligomycin B Product Citations

See how others have used Oligomycin B. Click on the entry to view the PubMed entry .

Citations 1 to 9 of 9 total

PMID: # 16257969 Tomasinsig, L. et al. 2006. J. Biol. Chem. 281: 383-391.

PMID: # 10444435 Jekabsons, MB. et al. 1999. Am. J. Physiol. 277: E380-E389.

PMID: # 2155067 Pesaturo, JA. et al. 1990. Circ. Res. 66: 696-709.

PMID: # 2577130 Burger, PM. et al. 1989. Neuron. 3: 715-720.

PMID: # 2903047 Hell, JW. et al. 1988. EMBO J. 7: 3023-3029.

PMID: # 2902091 Maycox, PR. et al. 1988. J. Biol. Chem. 263: 15423-15428.

PMID: # 6610568 Yeaman, SJ. et al. 1984. FEBS Lett. 172: 38-42.

PMID: # 6489513 Kerbey, AL. et al. 1984. FEBS Lett. 176: 115-119.

PMID: # 5664204 Jasper, DK. et al. 1968. J. Cell Biol. 38: 277-291.

Citations 1 to 9 of 9 total

Rated 5 out of 5 by SS from Tomasinsig et al Tomasinsig et al. (PubMed ID 16257969) used Oligomycin B, an antibiotic that acts as a nonselective ATP synthase inhibitor, to study energy depletion in mammalian cells. -SCBT Publication Review

Date published: 2015-04-26

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Oligomycin B (CAS 11050-94-5)

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References

Download SDS (MSDS)

Certificate of Analysis

Oligomycin B Product Citations

Oligomycin B (CAS 11050-94-5)

QUICK LINKS

References

Download SDS (MSDS)

Certificate of Analysis

Oligomycin B Product Citations

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